The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Mentioned books
88 snips
Nov 4, 2025 • 37min
The New SCIENCE of Energy Healing | Biohacking Updated : 1357
Harry Massey, a British entrepreneur and bioenergetics pioneer, shares his incredible journey from chronic fatigue to health empowerment after discovering energy medicine. He discusses how energy fields and frequency-imprinted remedies can enhance recovery and mitochondrial efficiency. The conversation reveals the capabilities of his innovative GEM wearable, which uses light and PEMF to deliver information for biological optimization. Harry also emphasizes integrating ancient wisdom with modern science, aiming for better emotional resilience and performance.
226 snips
Nov 2, 2025 • 22min
Your Body Has an Anti-Aging Switch (Here’s How to Turn It On) : 1356
Explore the intriguing idea that aging might be more about cellular health than simply getting older. Discover the importance of mitochondria in our well-being and how to enhance their function. Learn about REHIT workouts to boost mitochondrial health and the role of healthy fats in fueling your body's energy systems. Fasting techniques can trigger autophagy, your body’s natural cleaning process. Address stress with simple practices like breathwork and morning sunlight to enhance recovery and longevity.
108 snips
Oct 31, 2025 • 45min
What Happens When You Live Inside a Quantum Field? (Anti-Aging Secrets) : 1355
Philipp Samor von Holtzendorff-Fehling, a former telecom executive and CEO of Leela Quantum Tech, shares insights on quantum energy and its role in human performance. He discusses how quantum energy can combat EMF damage, enhance neuroplasticity, and aid self-healing. The conversation dives into practical applications of biofield technology, including improving sleep quality and emotional stability. Philipp reveals studies demonstrating measurable benefits of quantum tech on brain coherence and metabolism, alongside innovative uses in everyday items and water optimization.
249 snips
Oct 30, 2025 • 1h 10min
Master Stress in 10 Seconds with THIS Heartbeat Technique : 1354
Rollin McCraty, Ph.D., is the Director of Research at the HeartMath Institute, specializing in heart-brain coherence and stress regulation. He shares fascinating insights on how heart rate variability (HRV) influences performance and emotional well-being. Discover the benefits of coherence training for resilience and cognitive sharpness, and learn practical heart-focused breathing techniques. They also discuss the surprising effects of Earth's geomagnetic rhythms on our physiology and emotional states, highlighting the interconnectedness of nature and human health.
37 snips
Oct 28, 2025 • 43min
Biohacking Cannabis: The DNA Science of Plant Medicine : 1353
Len May, CEO of EndoDNA and a leader in genomics and medicinal cannabis, talks about revolutionizing health through personalized DNA insights. He reveals how genetics can determine your response to cannabis and psychedelics, enhancing mental health and performance. Throughout the discussion, Len emphasizes the importance of tailored formulations, the role of the endocannabinoid system, and using genetic data to avoid adverse reactions. With compelling anecdotes, he highlights how personalized cannabis strategies can dramatically improve life quality and well-being.
137 snips
Oct 26, 2025 • 18min
This Legal Focus Powder Beats Any Dopamine Detox : 1352
Discover how low brain energy can hinder focus and motivation, instead of just blaming dopamine. Learn about the crucial role of ATP in brain function and how stress and diet might damage your mitochondria. Explore biohacks to boost your energy production, including the surprising benefits of creatine as a powerful nootropic. This affordable supplement can enhance memory and resilience against stress, especially for vegans and those under pressure. Get tips on optimal dosing and hydration to maximize your brain's performance!
73 snips
Oct 24, 2025 • 6min
Biohacking News Weekly Update : 1351
In this gripping update, discover how 2,000 IU of vitamin D is becoming a game-changer in slowing telomere shortening and promoting biological youth. Uncover the secrets of the supercentenarian gene that reverses cardiac aging, potentially leading to superhuman longevity. The FDA shakes up the supplement world by closing the GRAS loophole, ensuring more accountability. Plus, learn how certain gut bacteria can trigger autophagy and explore the exciting future of health with digital twins and AI-driven health predictions.
144 snips
Oct 23, 2025 • 34min
How Biohackers Use Nicotine WITHOUT Getting Addicted : 1350
In this deep dive into nicotine, discover its surprising benefits as a nootropic. Learn how to optimize brain performance with low-dose nicotine while minimizing addiction risks. The discussion covers the importance of timing, stacking it with other supplements, and cycling to avoid tolerance. Delve into its potential in neuroprotection and implications for conditions like Alzheimer’s. Plus, hear practical tips on using patches and microdosing to enhance mental clarity and support overall health.
72 snips
Oct 21, 2025 • 57min
Why Women’s Joints Are Failing 10x Faster : 1349
Kiran Krishnan, a seasoned research microbiologist and Chief Scientific Officer at Calroy Health Sciences, shares his insights on the critical factors behind joint health decline. He reveals how systemic inflammation and mitochondrial dysfunction contribute to cartilage loss, highlighting that joint pain is often mishandled by conventional treatments. Krishnan discusses innovative solutions, including Cartigenix HP, which utilizes unique boswellia actives and celery seed extracts to combat inflammation. Furthermore, he emphasizes the importance of hormonal changes in midlife women, advocating for proactive measures to maintain joint health.
121 snips
Oct 19, 2025 • 13min
Why You Still Feel Tired And Foggy On A Perfect Diet : 1348
Explore the hidden disruptors that may be affecting your energy and focus, even with a perfect diet. From the impact of EMFs on sleep quality to the dangers of mold in your home, learn why it's crucial to consider your environment. Discover detox hacks to flush out toxins, rebuild essential nutrients, and unleash your mitochondrial power. Plus, practical tips for resetting your circadian rhythm and enhancing digestion, including the benefits of box breathing and gratitude in your daily routine.
