The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Mentioned books
103 snips
Nov 20, 2025 • 36min
The Methylene Blue Episode | Solo Biohacking Masterclass : 1366
Discover the power of methylene blue, a compound that can enhance energy, mood, and brain function when used correctly. Learn the importance of dosing, safety warnings, and potential interactions with medications. Explore its effects on mitochondria and neuroplasticity, alongside foundational biohacking strategies like ketosis and red light therapy. Dive into the clinical evidence for improved cognition and even fertility benefits. With practical tips for microdosing and tracking, this masterclass is a must for any biohacker!
53 snips
Nov 18, 2025 • 56min
The Tiny Implant Replacing Life-Changing Drugs | Biohacking Tools : 1365
In this discussion, Dr. Kevin J. Tracey, a pioneering figure in vagus nerve research and CEO of the Feinstein Institutes, shares groundbreaking insights on bioelectronic medicine. He reveals how targeted nerve stimulation might replace traditional drugs for conditions like rheumatoid arthritis, emphasizing the importance of specific pathways for inflammation control. Dr. Tracey also delves into the potential for vagal boosting to enhance longevity and metabolism while addressing safety concerns of neural implants. The future of health could be electric!
120 snips
Nov 16, 2025 • 15min
The Boring Secret Behind Celebrities Who Don’t Age : 1364
Discover how lobsters hold the key to staying young with a fascinating enzyme called telomerase. Understand telomeres and their critical role in aging as well as how celebrities utilize simple techniques to maintain their vitality. Learn about natural lifestyle changes like meditation that can activate telomerase in just 10 minutes a day. Explore stress management and exercise's pivotal roles in protecting telomeres. Tune in for practical tips to reshape your approach to aging and boost your biological resilience!
52 snips
Nov 14, 2025 • 10min
Biohacking News Weekly Update : 1363
Discover how high-flavanol cocoa extract can reduce cardiovascular deaths by 27%, with surprising gender-specific effects. Learn about the cutting-edge AI stethoscope for home diagnostics that predicts health issues before they arise. A surge in beef organ supplements reveals significant benefits for women's energy and well-being. New research showcases spirulina’s ability to boost collagen and protect DNA, while a proposal for health data privacy reform empowers users over their biological information. Get actionable biohacking tips to enhance your health!
108 snips
Nov 13, 2025 • 1h 4min
How to Build Muscle WITHOUT Lifting! Biohacker Longevity : 1362
Dr. Sten Stray-Gundersen, a leading researcher in metabolic physiology and blood flow restriction training, shares insights on building muscle without lifting weights. Discover how blood flow restriction (BFR) and intermittent hypoxia can enhance metabolism, increase longevity, and accelerate recovery with minimal effort. Sten discusses cutting-edge protocols for various demographics, including the elderly and injured, and explains the surprising hormonal benefits of BFR. Tune in for practical strategies that can optimize your workout efficiency and cognitive performance!
103 snips
Nov 11, 2025 • 39min
Why Motivation DOESN’T Work | Mental Biohacks : 1361
David Bayer, a transformational coach and author known for his work in personal growth, joins Dave Asprey to discuss the limitations of motivation in achieving true change. They explore how rewiring beliefs and perceptions is essential for sustainable transformation. Key topics include the role of neuroplasticity in shaping reality, how childhood trauma can be transformed into growth energy, and the importance of choosing empowering beliefs to reduce fear. They also emphasize the need for personal sovereignty in directing attention for broader cultural change.
138 snips
Nov 9, 2025 • 9min
New Japanese Walking Hack Burns More Fat Than 10,000 Steps : 1360
Explore a unique Japanese walking technique that can replace the need for 10,000 daily steps and significantly boost fat burning. Learn how this method improves metabolism, lowers stress, and enhances mitochondrial function in just 15–30 minutes. Discover why traditional fitness advice often backfires and how interval walking transforms ordinary strolls into powerful fat-burning sessions. Outdoor elements like sunlight and fresh air further amplify these effects, making walking an underrated fitness powerhouse.
49 snips
Nov 7, 2025 • 12min
Biohacking News Weekly Update : 1359
This week's findings reveal alarming risks associated with long-term melatonin use, linking it to increased heart failure rates. Bryan Johnson's innovative detox experiment shows a significant reduction in microplastics through extreme sauna therapy. Plus, urolithin A emerges as a champion for enhancing immune mitochondrial function. A breakthrough blood test could transform chronic fatigue syndrome diagnoses. Dive into AI modeling of cell behavior and discover how omega-3s can stabilize moods and reduce aggression.
47 snips
Nov 6, 2025 • 1h
The Strange Science Behind Tylenol and Heartbreak | Daniel Amen : 1358
Dr. Daniel Amen, a leading psychiatrist and brain health advocate, shares groundbreaking insights on how emotional and physical pain intersect within the brain. He explains techniques to break the “doom loop” of chronic pain and introduces havening, a method to calm emotions. Daniel reveals how Tylenol can alleviate emotional pain and emphasizes the importance of gut health in pain management. He discusses environmental toxins, the biopsychosocial approach to health, and practical tools to restore brain function and resilience.
88 snips
Nov 4, 2025 • 37min
The New SCIENCE of Energy Healing | Biohacking Updated : 1357
Harry Massey, a British entrepreneur and bioenergetics pioneer, shares his incredible journey from chronic fatigue to health empowerment after discovering energy medicine. He discusses how energy fields and frequency-imprinted remedies can enhance recovery and mitochondrial efficiency. The conversation reveals the capabilities of his innovative GEM wearable, which uses light and PEMF to deliver information for biological optimization. Harry also emphasizes integrating ancient wisdom with modern science, aiming for better emotional resilience and performance.
