The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Mentioned books
59 snips
May 12, 2026 • 1h 15min
The Real Reason She Loses Interest in Sex | John Gray : 1465
John Gray, famed author of Men Are from Mars, Women Are from Venus and biohacking counselor, joins to connect relationships with hormones and longevity. He discusses how partners raise or lower testosterone and estrogen. He covers societal testosterone decline, safety and desire, semen retention and discipline, lithium orotate, pre-digested protein, and practical listening strategies for restoring polarity and attraction.
96 snips
May 10, 2026 • 20min
This Italian Fasting Hack Breaks All The Rules Of Fasting : 1464
Learn an Italian-style fasting hack that triggers cellular cleanup while still eating 800–1100 calories. Hear why constant snacking wrecks gut rhythms and how abrupt water fasts can backfire. Get a clear five-day fasting mimicking protocol, prep steps, and safe refeeding tactics to rebuild your microbiome. Practical timing, sleep, and frequency tips for long-term benefits.
41 snips
May 8, 2026 • 11min
Pandemic Fever Is BACK, Testosterone and Brain Tumors, Rabies, and Dog Flu : 1463
Research suggesting testosterone may slow glioblastoma growth and why hormone panels now matter. A CDC testing pause creating dangerous rabies diagnostic delays and what to do after an exposure. A court decision that could reshape telehealth access to peptides, hormones, and mailed treatments. New zoonotic threats from dog and cow viruses and a hantavirus ship outbreak that highlights building resilient biology.
33 snips
May 7, 2026 • 37min
iPhone Poisoning Is REAL: Here's How To Reverse the Hidden Damage | Quantum Upgrade : 1462
Philippe Samor von Holtzendorff-Fehling, entrepreneur and energy healer who founded Leela Quantum Tech, explains remote quantum energy fields. He discusses how these fields aim to harmonize EMF effects on brain waves, HRV, blood and recovery. The conversation covers EEG evidence, placebo-controlled trials, EV and Starlink concerns, customization for sleep and performance, and effects on kids and pets.
49 snips
May 5, 2026 • 54min
Eat These Foods + Spices for 8 Weeks To Get 3 Years Younger | Kara Fitzgerald : 1461
Dr. Kara Fitzgerald, naturopathic doctor and researcher who studies epigenetic aging, shares how targeted diet, polyphenol-rich foods, supplements, and meditation can rapidly lower biological age. They discuss Yamanaka factors and safer Yamanaka mimetics, why diverse polyphenols matter, delivery strategies to avoid plant toxins, oxalate concerns, and high-leverage targets like ovarian rejuvenation.
61 snips
May 3, 2026 • 15min
This 9,000-Year-Old Ritual Cleared 15 Years Of Brain Fog : 1460
A 9,000-year-old heat-and-cold ritual is explored as a way to reset a nervous system stuck in survival mode. Practical routines for infrared sauna, contrast therapy, and breathing techniques are outlined. The discussion focuses on completing stress cycles, why supplements alone fall short, and how routine recovery practices can restore lasting mental clarity.
70 snips
May 1, 2026 • 11min
Selfies Predict Cancer, Dirty Feed, Bone Vibration, and more... : 1459
Stories cover how natural mud playgrounds reshape kids' skin microbes and boost immune genes. A large study links rotating multiple exercise types to markedly lower mortality. AI-derived facial aging from serial photos predicts cancer survival better than common blood markers. Practical tips include monthly selfie monitoring and vibration tech to stimulate bone density.
83 snips
Apr 30, 2026 • 49min
The Strangest Thing I Do Every Morning for 15 Minutes | Brad Pitzele : 1458
Brad Pitzele, founder of One Thousand Roads who rebuilt his health using oxygen and red light therapies. He explains 15-minute Exercise With Oxygen Therapy, how oxygen plus red/infrared light supercharges mitochondria, and the idea of tissue-level oxygen starvation called pseudo-hypoxia. They discuss timing, stacking the therapies, nitric oxide, circulation and practical at-home setups.
36 snips
Apr 28, 2026 • 1h 5min
How Beef Is Destroying Your Hormones – Cynthia Thurlow : 1457
Cynthia Thurlow, nurse practitioner and women’s hormonal health expert, and author focused on intermittent fasting and midlife care. She unpacks why perimenopause often starts in the mid-30s. Short takes on the gut-ovarian axis, mold and xenoestrogens in beef/dairy, histamine’s role in hot flashes, statins’ metabolic effects, and trauma’s acceleration of ovarian aging.
47 snips
Apr 26, 2026 • 11min
Supercharge Your Immunity In 4 Weeks With THIS Ancient Fruit : 1456
They explore why immune function falters in your 40s and the mitochondrial breakdown behind it. The conversation covers mitophagy, how it stalls with age, and the ancient fruit linked to a key molecule. They explain why food sources often fail and introduce a supplement that delivers the compound directly. Clinical trial timing and reported immune changes over four weeks are also discussed.
