Astral Codex Ten Podcast

Link: https://slatestarcodex.com/2019/12/18/acc-should-gene-editing-technologies-be-used-in-humans/ [This is an entry to the 2019 Adversarial Collaboration Contest by Nita J and Patrick N.] Introduction In October 2018, the world's first genetically edited babies were born, twin girls given the pseudonyms Lulu and Nana; Chinese scientist He Jiankui used CRISPR technology to edit the CCR5 gene in human embryos with the aim of conferring resistance to HIV. In response to the international furor, China began redrafting its civil code to include regulations that would hold scientists accountable for any adverse outcomes that occur as the result of genetic manipulation in human populations. Now, reproductive biologists at Weill Cornell Medicine in New York City are conducting their own experiment designed to target BRCA2, a gene associated with breast cancer, in sperm cells. While sometimes considered controversial, gene editing has been used as a last resort to cure some diseases. For example, a precursor of CRISPR was successfully used to cure leukemia in two young girls when all other treatment options had failed. Due to its convenience and efficiency, CRISPR offers the potential to fight cancer on an unprecedented level and tackle previously incurable genetic diseases. However, before we start reinventing ourselves and mapping out our genetic futures, maybe we should take a moment to reevaluate the risks and repercussions of gene editing and rethink our goals and motives.

Link: https://slatestarcodex.com/2019/12/17/acc-should-we-colonize-space-to-mitigate-x-risk/ [This is an entry to the 2019 Adversarial Collaboration Contest by Nick D and Rob S.] I. Nick Bostrom defines existential risks (or X-risks) as "[risks] where an adverse outcome would either annihilate Earth-originating intelligent life or permanently and drastically curtail its potential." Essentially this boils down to events where a bad outcome lies somewhere in the range of 'destruction of civilization' to 'extermination of life on Earth'. Given that this has not already happened to us, we are left in the position of making predictions with very little directly applicable historical data, and as such it is a struggle to generate and defend precise figures for probabilities and magnitudes of different outcomes in these scenarios. Bostrom's introduction to existential risk​ provides more insight into this problem than there is space for here. There are two problems that arise with any discussion of X-risk mitigation. Is this worth doing? And how do you generate the political will necessary to handle the issue? Due to scope constraints this collaboration will not engage with either question, but will simply assume that the reader sees value in the continuation of the human species and civilization. The collaborators see X-risk mitigation as a "​Molochian​" problem, as we blindly stumble into these risks in the process of maturing our civilisation, or perhaps a twist on the tragedy of the commons. Everyone agrees that we should try to avoid extinction, but nobody wants to pay an outsized cost to prevent it. Coordination problems have been solved throughout history, and the collaborators assume that as the public becomes more educated on the subject, more pressure will be put on world governments to solve the issue.

Link: https://slatestarcodex.com/2019/12/12/acc-does-calorie-restriction-slow-aging/ [This is an entry to the 2019 Adversarial Collaboration Contest by the delightfully-pseudonymous Adrian Liberman and Calvin Reese.] About the Authors: Adrian Liberman is currently a PhD student in biology at a university in the mid-Atlantic. He previously worked at the National Institute of Aging and remains actively interested in gerontology and the biological study of aging. Calvin Reese is an author with a BS in Biology. He has always been interested in the possibility of life extension by calorie restriction. Recently, he has reexamined the subject after undertaking a series of intermittent fasts for weight loss reasons. Calvin believes CR extends life; Adrian has long been skeptical. Introduction: Is food making us old? We all agree that food is delicious, and we also all agree that too much food is bad for us, but exactly how bad is it? Various academics have proposed that too much food actually accelerates the aging process, and reducing our food intake via calorie restriction (CR) is one of the most accessible and available methods of extending human life. While billionaires pump vast fortunes into increasingly far-fetched stem cell treatments and consciousness transfers, CR advocates contend that they can get a 10-20% increase in their natural lifespans simply by eating a little less. If true, CR raises a question of enormous significance to gerontology and the science of aging: are our diets aging us one calorie at a time? And if so, can we stop it?

Link: https://slatestarcodex.com/2019/12/11/acc-is-eating-meat-a-net-harm/ [This is an entry to the 2019 Adversarial Collaboration Contest by David G and Froolow. Please also note my correction to yesterday's entry.] Introduction Many people around the world have strong convictions about eating animals. These are often based on vague intuitions which results in unproductive swapping of opinions between vegetarians and meat eaters. The goal of this collaboration is to investigate all relevant considerations from a shared frame of reference. To help ground this discussion we have produced a decision aid making explicit everything discussed below. You can download it here and we encourage you to play around with it. The central question is whether factory farmed animal lives are worth living; the realistic alternative to meat eating is not a better life but for those animals to not exist in the first place. We begin by investigating which animals are conscious. Then, we compare the happiness literature to the conditions under which animals are factory farmed to figure out if from their perspective non-existence is preferable. And finally, we survey the more easily measurable impacts of meat eating on environment, finance, and health.

Link: https://slatestarcodex.com/2019/12/10/acc-is-infant-circumcision-ethical/ [This is an entry to the 2019 Adversarial Collaboration Contest by Joel P and Missingno] "They practise circumcision for cleanliness' sake; for they would rather be clean than more becoming." – Herodotus, The Histories – 2.37 The debate over circumcision in the Western world today is surprisingly similar to the conflict that Greeks and Egyptians faced 2500 years ago. Supporters tend to emphasize its hygiene and health benefits; opponents tend to call it cruel or to emphasize its deviation from the natural human form. In this adversarial collaboration we address medical aspects, sensitivity and pleasure, and ethical aspects of infant circumcision. Effect on penile cancer Circumcision greatly reduces the relative rate of penile cancer, a relatively uncommon malignancy in developed nations which kills a little over 400 American men each year. Denmark, while it has one of the lowest rates of penile cancer for a non-circumcising country, nevertheless has 10x the rate of penile cancer as Israel – where almost all men are circumcised. Likewise, a Kaiser Permanente study of patients with penile cancer found that 16% of patients with carcinoma in situ had been circumcised; only 2% of patients with invasive penile cancer had been circumcised. Since the circumcision rate of Kaiser patients of the appropriate age was ~50%, this is in line with the 90% reduction.

Link: https://slatestarcodex.com/2019/12/09/2019-adversarial-collaboration-entries/ Thanks to everyone who sent in entries for the 2019 adversarial collaboration contest. Remember, an adversarial collaboration is where two people with opposite views on a controversial issue work together to present a unified summary of the evidence and its implications. In theory it's a good way to make sure you hear the strongest arguments and counterarguments for both sides – like hearing a debate between experts, except all the debate and rhetoric and disagreement have already been done by the time you start reading, so you're just left with the end result. See the 2018 entries for examples. Six teams submitted collaborations for this year's contest. I'll list them here for now, and the names will turn into links as I post them over the next two weeks. They are: 1. "Is infant circumcision ethical?" by Joel P and Missingno 2. "Is eating meat a net harm?" by David G and Froolow 3. "Does calorie restriction slow aging?" by Adrian L and Calvin R 4. "Should we colonize space to mitigate x-risk?" by Nick D and Rob S 5. "Should gene editing technologies be used in humans" by Nita J and Patrick N 6. "Will automation lead to economic crisis?" by Doug S and Erusian (if any of you are unhappy with how I named you or titled your piece, let me know) At the end of the two weeks, I'll ask readers to vote for their favorite collaboration, so try to remember which ones impress you. I think we're all winners by getting to read these – but the actual winners get that plus $2500 in prize money. Thanks again to everyone who donates to the Patreon for making that possible. Please put any comments about the contest itself here, not on the individual entries.

Link: https://slatestarcodex.com/2019/12/04/symptom-condition-cause/ On my recent post on autism, several people chimed in to say that "autism" wasn't a unitary/homogenous category. It probably lumps together many different conditions with many different causes. It's useless to speculate on the characteristics of "autism" until it can be separated out further. I get this every time I talk about a psychiatric condition. The proponents of this view seem to think they're speaking a shocking heresy that overturns the psychiatric establishment. But guys, we know this kind of stuff. Psychiatric diagnoses don't have to perfectly match underlying root causes to be useful. Suppose a patient comes to you with difficulty breathing, excessive sweating, anxiety, and extreme discomfort when lying down flat. You recognize these as potential signs of pulmonary edema, ie fluid in the lungs. You do an x-ray, confirm the diagnosis, and prescribe symptomatic treatment – in this case, supplemental oxygen. All of this is good work. But you can have fluid in your lungs for lots of different reasons. Most of the time it's heart failure, but sometimes it's kidney failure, pneumonia, drug overdose, smoke inhalation, or altitude sickness. Some of these causes will have slightly different symptoms, which an alert doctor can notice.

Link: https://slatestarcodex.com/2019/11/28/ssc-meetups-everywhere-retrospective/ Slate Star Codex has regular weekly-to-monthly meetups in a bunch of cities around the world. Earlier this autumn, we held a Meetups Everywhere event, hoping to promote and expand these groups. We collected information on existing meetups, got volunteers to create new meetups in cities that didn't have them already, and posted times and dates prominently on the blog. During late September and early October, I traveled around the US to attend as many meetups as I could. I hoped my presence would draw more people; I also wanted to learn more about meetups and the community and how best to guide them. Buck Shlegeris and a few other Bay Area effective altruists came along to meet people, talk to them about effective altruism, and potentially nudge them into the recruiting pipeline for EA organizations. Lots of people asked me how my trip was. In a word: exhausting. I got to meet a lot of people for about three minutes each. There were a lot of really fascinating people with knowledge of a bewildering variety of subjects, but I didn't get to pick their minds anywhere as thoroughly as I would have liked. I'm sorry if I talked to you for three minutes, you told me about some amazing project you were working on to clone neuroscientists or eradicate bees or convert atmospheric CO2 into vegan meat substitutes, and I mumbled something and walked away. You are all great and I wish I could have spent more time with you. I finally got to put faces to many of the names I've interacted with through the years. For example, Bryan Caplan is exactly how you would expect, in every way. Also, in front of his office, he has a unique painting, which he apparently got by asking a Mexican street artist to paint an homage to Lord of the Rings. The artist had never heard of it before, but Bryan described it to him very enthusiastically, and the completely bonkers result is hanging in front of his office. This is probably a metaphor for something.

Link: https://slatestarcodex.com/2019/11/26/mental-mountains/ I. Kaj Sotala has an outstanding review of Unlocking The Emotional Brain; I read the book, and Kaj's review is better. He begins: UtEB's premise is that much if not most of our behavior is driven by emotional learning. Intense emotions generate unconscious predictive models of how the world functions and what caused those emotions to occur. The brain then uses those models to guide our future behavior. Emotional issues and seemingly irrational behaviors are generated from implicit world-models (schemas) which have been formed in response to various external challenges. Each schema contains memories relating to times when the challenge has been encountered and mental structures describing both the problem and a solution to it. So in one of the book's example cases, a man named Richard sought help for trouble speaking up at work. He would have good ideas during meetings, but felt inexplicably afraid to voice them. During therapy, he described his narcissistic father, who was always mouthing off about everything. Everyone hated his father for being a fool who wouldn't shut up. The therapist conjectured that young Richard observed this and formed a predictive model, something like "talking makes people hate you". This was overly general: talking only makes people hate you if you talk incessantly about really stupid things. But when you're a kid you don't have much data, so you end up generalizing a lot from the few examples you have.

Link: https://slatestarcodex.com/2019/11/20/book-review-all-therapy-books/ I. All therapy books start with a claim that their form of therapy will change everything. Previous forms of therapy have required years or even decades to produce ambiguous results. Our form of therapy can produce total transformation in five to ten sessions! Previous forms of therapy have only helped ameliorate the stress of symptoms. Our form of therapy destroys symptoms at the root! All psychotherapy books bring up the Dodo Bird Verdict – the observation, confirmed in study after study, that all psychotherapies are about equally good, and the only things that matters are "nonspecific factors" like how much patients like their therapist. Some people might think this suggests our form of therapy will only be about as good as other forms. This, all therapy books agree, would be a foolish and perverse interpretation of these findings. The correct interpretation is that all previous forms of therapy must be equally wrong. The only reason they ever produce good results at all is because sometimes therapists accidentally stumble into using our form of therapy, without even knowing it. Since every form of therapy is about equally likely to stumble into using our form of therapy, every other form is equally good. But now that our form of therapy has been formalized and written up, there is no longer any need to stumble blindly! Everyone can just use our form of therapy all the time, for everything! Nobody has ever done a study of our form of therapy. But when they do, it's going to be amazing! Nobody has even invented numbers high enough to express how big the effect size of our form of therapy is going to be!