Gladden Longevity Podcast

The CDC is now categorizing insufficient sleep as an epidemic, associating the problem with increased risk for numerous health conditions and injury. Mark and Dr. Gladden discuss the slippery slope of poor sleep habits, the "fly-wheel" effect that can have a negative impact on your health in so many different ways. Sufficient, quality sleep supports our health, creativity, intellectual capacity and much more while we're awake. Mark and Dr. Gladden explain the natural, complex process of the sleep-wake cycle. They offer a number of suggestions to reduce things that often hinder good sleep and recommend good habits to improve sleep.

First, Mark and Dr. Gladden discuss the difference between body types that are more comfortable in warmer or colder temperatures, which can be determined with genetic testing through services like Athletigen. They also discuss how the body performs better when it is challenged by different extremes. Next, they discuss non-alcoholic fatty liver disease, which is an epidemic that is the most common liver disorder in developed countries. In a traditional medical model, this diagnosis is considered irreversible. Mark's father died from this disease, and Mark was also diagnosed with a cirrhotic liver. He was referred to a liver transplant specialist. Dr. Gladden and Mark walk through a number of measures that Mark took, outside of traditional medicine with Gladden's guidance, to improve his condition. They talk about his incredible results, because his customized plan was based very specifically off his genetics.

Mark and Dr. Gladden welcome Dan Sullivan of Strategic Coach back to the show to talk about the thinking behind his latest book, My Plan For Living To 156. He discusses his mindset shift toward greater longevity, rather than believing he would only live about as long as his parents. Dan talks about one of the most important changes he's made in his life for his mindset. Dr. Gladden talks about the difference between being committed to a question versus being married to an answer. They talk about how the mind has the ability to overcome so many physical conditions, so it is key to reprogramming the body. Dan goes through some of his plans for getting to 156, including how he's developing good habits and strengths. SPECIAL GUEST Dan Sullivan is founder and president of The Strategic Coach Inc. A visionary, an innovator, and a gifted conceptual thinker, Dan has over 35 years' experience as a highly regarded speaker, consultant, strategic planner and coach to entrepreneurial individuals and groups. Dan's strong belief in and commitment to the power of the entrepreneur is evident in all areas of Strategic Coach® and its successful coaching program, which works to help entrepreneurs reach their full potential in both their business and personal lives. He is author of over 30 publications, including The Great Crossover, The 21st Century Agent, Creative Destruction and How The Best Get Better®. He is co-author of The Laws of Lifetime Growth and The Advisor Century. Dan is married to Babs Smith, his partner in business and in life. They jointly own and operate The Strategic Coach Inc., with offices in Toronto, Chicago, and the U.K. Follow Dan on Twitter @StrategicCoach and Facebook: https://www.facebook.com/StrategicCoach/ For information on his business strategies and programs, visit https://www.strategiccoach.com/ Get a free copy of My Plan for Living to 156

At what age were you at your very best physically, mentally and spiritually? Traditional medicine sets the "standard" about your age, deciding what levels indicate health. This means accepting when things start to go wrong rather than intervening medically. Traditional "anti-aging" experts ask how to turn the clock back. A third set considers how we become better than ever at any age. Dr. Gladden and Mark discuss the way aerobic activity and lower stress improves brain function, as well as hormone balance and the introduction of peptides to enhance mental health. Dr. Gladden expands on hormone balance and its function in health and performance. Consider what you're doing to reclaim or exceed your peak. How good could you be?

On this episode, Dr. Gladden and Mark talk about how the brain-body connection impacts health. Dr. Gladden believes that people actually need to think of their body asa brain because the neurological system runs throughout the body. The discuss the power of the brain in helping your body heal or possibly holding your body back. If you're not treating the whole body, recovery from an injury or illness may be impeded because the whole system is out of balance. Behaviors and mindset play a major role in health, both in the positive and negative. In the reverse, problems in your body can affect the way your brain works as well. They consider the mindset we need to overcome the sick care system we have, to try and restore ourselves to our peak health. Dr. Gladden suggests things you can do to help retrain your brain, including meditation, transcranial direct stimulation and hypnosis.

Dr. Jeffrey Marksberry joins Mark and Dr. Gladden on this episode to discuss the electrostimulation device Alpha-Stim, which runs a low microcurrent through the brain or body. In the brain, it simulates endorphins and serotonin to treat anxiety, insomnia and depression. In the body, it treats peripheral pain. The nervous system is 98% electrically induced, and Dr. Marksberry explains how the treatment works for patients. They discuss how this device can help enhance mental function, exploring the possibilities when paired with other treatments for improved human performance. Dr. Gladden describes some of his own experiences with Alpha-Stim as well. About the guest: Dr. Jeffrey Marksberry serves as the Chief Science & Clinical Officer for Electromedical Products International Inc. (EPI). Dr. Marksberry has more than ten years of experience in medical education as a special consultant for two international medical schools. He also has expertise in medical licensure regulations for all 50 states and sovereign Native American governments as well as Canada, Australia, New Zealand and The Netherlands. His focus areas included writing curriculum for continuing medical education programs for medical schools and universities. In 2014, Dr. Marksberry was granted the designation of Certified Clinical Research Professional by the Society of Clinical Research Associates. In 2015, Dr. Marksberry co-authored a chapter in the book Bioelectromagnetic and Subtle Energy Medicine 2nd Edition. (Kirsch DL and Marksberry JM. The Evolution of Cranial Electrotherapy Stimulation for Anxiety, Insomnia, Depression and Pain and Its Potential for Other Indications, p 189-209. Bioelectromagnetic and Subtle Energy Medicine 2nd Edition, Rosch, Paul J. (Ed) CRC Press Boca Raton.)

On this episode, Mark and Dr. Gladden invite Dr. V.A. Shiva Ayyadurai to tell his story, from his childhood in India watching his grandmother practice traditional medicine on the weekends to working in the U.S. in medical research and running for U.S. Senate in Massachusetts. Shiva has grown many businesses that focus on technology, with a frequent interest in healthcare. He discusses his various inventions and breakthroughs that stem from his education in the U.S. and the practice of medicine he observed as a child. They discuss how different body types have different needs, including diet and medicine. Your body is a system, and different deficiencies bring your system out of balance. Finding those deficiencies to bring your body back into balance is crucial to health. The current health system is based on wartime crisis management for health, treating one problem quickly, rather than prevention and preemptive medicine for the sake of the whole system. Shiva discusses how the technology he created, CytoSolve®, as an alternative to the very cumbersome and expensive traditional model of drug development. CytoSolve allows for complex models of molecular pathways to be able to test medicines and other compounds mathematically first. About the guest: Dr. V.A. Shiva Ayyadurai, the inventor of email and polymath, holds four degrees from MIT, including his PhD in Biological Engineering. He is a world-renowned systems scientist, Fulbright Scholar, Lemelson-MIT Awards Finalist, First Outstanding Scientist and Technologist of Indian Origin (STIO), Westinghouse Science Talent Honors Award recipient, and was nominated for the U.S. National Medal of Technology and Innovation. On August 30, 1982, the US government recognized Dr. Ayyadurai as the inventor of email by awarding him the first Copyright for "Email" at a time when Copyright was the only way to protect software inventions. His interest in human health began early, when as a child, he observed his grandmother, a village farmer and healer, practice India's oldest system of traditional medicine. This motivated his future study and research in systems biology at MIT, leading to his discovery of Systems Health®, a major breakthrough that provides an integrative framework linking eastern and western medicine. His latest invention CytoSolve®, emerging from his doctoral research at MIT, provides a revolutionary platform for modeling diseases from Cancer to Alzheimer's to discover drugs at a fraction of the time and cost. He is running for US Senate as an independent in the state of Massachusetts on the policies of clean government, real health, real jobs. Visit Shiva's website, https://shiva4senate.com/. Buy his books here. Follow Shiva on Twitter: @va_shiva.

On this episode, Dr. Anne Truong of Truong Rehabilitation Center joins Dr. Gladden, Mark and Robb to discuss how she has been using platelet rich plasma to treat sexual dysfunction in men. Dr. Anne describes the procedure of injecting platelet rich plasma and the kind of results she has seen in her patients. She also talks about the complementary therapies, such as hormone replacement and shockwave therapy, that would be used to address the whole system. You can learn more by downloading her book, Erectile Dysfunction Fix. Platelet rich plasma is also used to help women with sexual dysfunction and improving libido and sexual response. Dr. Gladden talks about how stem cell therapy is starting to be used to help patients who have had their prostates removed. Listen to our previous episode on stem cell therapy here. Special Guest: Anne N. Truong, M.D. is the sole founder and owner of Truong Rehabilitation Center. Dr. Truong has extensive experience in the non-operative management of musculoskeletal injuries using state-of-the-art techniques such as Trigger Point injections and Regenerative Therapies, ultra-sound-guided injections to joints and muscles, medical acupuncture and osteopathic manipulation. She has been doing regenerative cell therapy since 2006, also has taught numerous doctors all over the world on regenerative medicine. Her approach is to decrease pain and to restore strength and function without medications and/or surgery. Once pain reduction is achieved, she prescribes a personal wellness exercise program for patients. Drawing upon her many areas of experience and expertise, as well as the capabilities of her allied health staff, Dr. Truong is able to deliver individualized treatment for each patient. Dr. Truong is Board Certified in Physical Medicine and Rehabilitation, and Electrodiagnostic Medicine. She received her B.A. in Biology from the University of California, Berkley and her M.D. from the University of Nevada, School of Medicine. Dr. Truong completed her Internal Medicine Internship at the University of California, Irvine. She attended Baylor College of Medicine, one of the nation's top residency programs for Pain Management and Rehabilitation. She currently serves as a Clinical Assistant Professor for Virginia Commonwealth University at the Medical College of Virginia. On January 26, 2018, Dr. Truong was awarded Entrepreneur of the Year in the Fredericksburg area by the Fredericksburg Regional Chamber of Commerce. She has been named to Top Doctors in 2012, 2013, and 2014 by Northern Virginia Magazine. She has served as the President of the Virginia Physical Medicine and Rehabilitation Society since 2005. Dr. Truong resides with her husband and two children in the Fredericksburg area. Dr. Anne Truong, M.D. was recently appointed Women Entrepreneur Ambassador by Women's Entrepreneurship Day Organization (WEDO). She will be representing the state of Virginia beginning in January 2018. WEDO is a privately-owned philanthropic organization with a mission and movement to empower women and girls globally, and alleviate poverty worldwide. WEDO Ambassadors will raise awareness of their business, make valuable connections, gain access to a premier network of extraordinary members and most importantly be a part of the greatest movement to empower women in business to alleviate poverty. According to WEDO, women account for 85% of consumer purchases and control $20 trillion in global spending. At the same time, they perform 66% of the world's work (both paid and unpaid), yet only earn 10% of the world's income. In the U.S., there are approximately 10,000,000 woman-owned businesses. 1 in 3 women in America lives in poverty and of the 1.3M people living in severe poverty globally, 70% which are women and girls. When asked how this role will serve the Fredericksburg community directly, Truong said "I'm honored to be appointed. I want to be able to inspire and empower women who want to be entrepreneurs and own their own business. I hope I can be a resource for women entrepreneurs in the Fredericksburg area." Dr. Truong is now the Assistant Professor in the Department of Internal Medicine, Discipline of Physical Medicine and Rehabilitation. She is the clinical Preceptor for 3rd and 4th year medical students from VCOM (The Edward Via College of Osteopathic Medicine at Virginia Tech) at Truong Rehabilitation Center.

On this episode, Dr. Gladden, Mark and Robb discuss the problem of senescent cells in the body. Senescent cells stop dividing, but they don't die off through apoptosis. Rather than making way for new cells, they can become dysfunctional, release toxins and can contribute to aging and disease. Robb shares a study on senolytic drugs, which helps induce the death of senescent cells, showing promise so far in helping mice live longer. They discuss some habits that can help maintain telomere length to prolong the longevity of cells. They also cover some of the treatments that the medical community is exploring to deal with senescent cells. They talk about how stress helps the body stay healthier and that balance in your body and vigilance in healthy habits are needed to promote longevity.

Matthew Feshbach, founder and CEO of Ambrose Cell Therapy, joins the conversation to share information about stem cell research and treatment using stem cells. Feschbach explains the difference between types of stem cells and which are most effective for reparative therapies. They talk about why the body degenerates with age, related to stem cells. Feshbach describes the process and technology his clinic uses to harvest mesenchymal stem cells for use in therapy. They consider some of the regulatory issues involved in stem cell therapy. Feshbach describes some of the amazing results that have been seen in patients who have received the therapy to treat significant health issues. He explains what sort of lifestyle choices can optimize results from this kind of treatment. Also on the podcast, Mark and Dr. Gladden discuss the problem with staying in your comfort zone, both physically and mentally. In contrast, they describe the environments in which we grow and thrive. Special Guest: Matthew (Matt) Feshbach is the Founder and CEO of AMBROSE Cell Therapy. AMBROSE was founded in 2017 with the mission: To help people with chronic degenerative diseases improve symptoms, function and quality of life with adult stem cell therapy. Matt has taken an unconventional path throughout his business career. He did not attend college but instead taught tennis at private homes in Silicon Valley. Through that experience he developed professional and personal relationships with a number of prominent investment managers, who inspired him to study securities analysis and begin investing himself. This led to the co-founding, with his brothers Kurt and Joe, of Feshbach Bros in 1982. Feshbach Bros. managed the first "short-only" hedge fund. Assets under management grew from $20,000 to $1 Billon in 9 years. Matt's investment career, through the ups and downs of the stock market, spanned more than 30 years. In 2009 he and his brother, Joe, began researching adult stem cells and their potential, due to their interest in a publicly traded company. They spoke to researchers from all over the world - Israel to Japan, Holland to Spain, New York to Los Angeles, Chicago to Dallas and so on - to understand the best source of adult stem cells as well as the science, technologies and unmet medical needs they could potentially address. As a result of their research, they came to have a well-informed opinion that fat (adipose) tissue is the most accessible, abundant and potent source of adult stem and regenerative cells. As well, that the mixed population of adipose-derived stem and regenerative cells (ADRCs) could be used to address a broad spectrum of chronic diseases. This has now been validated in the published medical literature. 1 2 3 Along with his brother, Matt founded Okyanos (Oh-key-ah-nos) Cell Therapy in August 2011 in Freeport, Bahamas. The Greek God of Rivers, "Okyanos" symbolizes restoration of blood flow, which is an important mechanism of action of ADRCs. Shortly after helping to create Okyanos, Matt's brother, Joe, sadly died of a cardiac arrest. Joe's death prompted Matt to be even more dedicated his purpose to help patients with chronic disease with their own adult stem cells. In the Bahamas, he drafted the framework for what developed into the Bahamas Stem Cell Research and Therapy Act, while concurrently building and staffing Okyanos. Due to the uncompromising standards set by Matt, Okyanos came to be known as the first cell therapy center of excellence in the world. The passage of House Bill 810, Charlie's Law, in Texas paved the way for Matt to once again set a new standard in cell therapy for complex chronic disease. To be specific, Charlie's Law allows the use of investigational adult stem cell treatments in Texas for patients that have been diagnosed with a terminal illness or severe chronic disease. This is a Right-to-Try Law. The U.S Constitution - Tenth Amendment states - "The powers not delegated to the United States by the Constitution, nor prohibited by it to the States, are reserved to the States respectively, or to the people." As such FDA has not taken action against drug companies or providers in the 28 states with medical marijuana laws and the 38 states with laws allowing patients who are terminally ill the right to try experimental drugs without FDA approval (Right to try Laws), respectively. Matthew Feshbach has combined his 3 decades of investment experience with his personal purpose to help others and, for a non-medical person, extraordinary knowledge of the science, technology and protocols of adult stem cell therapy to bring the highest standards of safety, care and potential effectiveness to patients in need. 1 A Nguyen, A et al Stromal vascular fraction: A regenerative reality? Part 1: Current concepts and review of the literature Journal of Plastic, Reconstructive & Aesthetic Surgery (2016) 69, 170e179 2 Guo et al Stromal vascular fraction: A regenerative reality? Part 2: Current concepts and review of the literature Journal of Plastic, Reconstructive & Aesthetic Surgery (2016) 69, 180e188 3 JK Fraser PhD and S Kesten MD Autologous Adipose Derived Regenerative Cells: A platform for therapeutic applications Advanced Wound Healing Surgical Technology International XXIX You can contact Feschbach via email or by phone: matt@ambrosecelltherapy.com (727) 743-1510