Gladden Longevity Podcast

Matt Feshbach of AMBROSE Cell Therapy comes back to Living Beyond 120 to talk more about stem cell therapy, bringing stories of real outcomes that patients have experienced after treatment. They offer an overview of stem cell therapy first, including how Feshbach harvests cells for treatment. Feshbach discusses the therapeutic cells located in a person's fat and what role these play in the therapy. They also consider what kind of conditions can benefit from stem cell therapy. Some of the actual patient stories Feshbach covers are the treatment of people who suffer from arthritis, kidney failure, emphysema, Alzheimer's, traumatic injury and more. They talk about how stem cell therapy needs to be utilized in a way that makes sense, as well as what people can do to improve their outcomes if they do take advantage of this kind of treatment. About Matt Feshbach: Matthew (Matt) Feshbach is the Founder and CEO of AMBROSE Cell Therapy. AMBROSE was founded in 2017 with the mission: To help people with chronic degenerative diseases improve symptoms, function and quality of life with adult stem cell therapy. Matt has taken an unconventional path throughout his business career. He did not attend college but instead taught tennis at private homes in Silicon Valley. Through that experience he developed professional and personal relationships with a number of prominent investment managers, who inspired him to study securities analysis and begin investing himself. This led to the co-founding, with his brothers Kurt and Joe, of Feshbach Bros in 1982. Feshbach Bros. managed the first "short-only" hedge fund. Assets under management grew from $20,000 to $1 Billon in 9 years. Matt's investment career, through the ups and downs of the stock market, spanned more than 30 years. In 2009 he and his brother, Joe, began researching adult stem cells and their potential, due to their interest in a publicly traded company. They spoke to researchers from all over the world - Israel to Japan, Holland to Spain, New York to Los Angeles, Chicago to Dallas and so on - to understand the best source of adult stem cells as well as the science, technologies and unmet medical needs they could potentially address. As a result of their research, they came to have a well-informed opinion that fat (adipose) tissue is the most accessible, abundant and potent source of adult stem and regenerative cells. As well, that the mixed population of adipose-derived stem and regenerative cells (ADRCs) could be used to address a broad spectrum of chronic diseases. This has now been validated in the published medical literature. 1 2 3 Along with his brother, Matt founded Okyanos (Oh-key-ah-nos) Cell Therapy in August 2011 in Freeport, Bahamas. The Greek God of Rivers, "Okyanos" symbolizes restoration of blood flow, which is an important mechanism of action of ADRCs. Shortly after helping to create Okyanos, Matt's brother, Joe, sadly died of a cardiac arrest. Joe's death prompted Matt to be even more dedicated his purpose to help patients with chronic disease with their own adult stem cells. In the Bahamas, he drafted the framework for what developed into the Bahamas Stem Cell Research and Therapy Act, while concurrently building and staffing Okyanos. Due to the uncompromising standards set by Matt, Okyanos came to be known as the first cell therapy center of excellence in the world. The passage of House Bill 810, Charlie's Law, in Texas paved the way for Matt to once again set a new standard in cell therapy for complex chronic disease. To be specific, Charlie's Law allows the use of investigational adult stem cell treatments in Texas for patients that have been diagnosed with a terminal illness or severe chronic disease. This is a Right-to-Try Law. The U.S Constitution - Tenth Amendment states - "The powers not delegated to the United States by the Constitution, nor prohibited by it to the States, are reserved to the States respectively, or to the people." As such FDA has not taken action against drug companies or providers in the 28 states with medical marijuana laws and the 38 states with laws allowing patients who are terminally ill the right to try experimental drugs without FDA approval (Right to try Laws), respectively. Matthew Feshbach has combined his 3 decades of investment experience with his personal purpose to help others and, for a non-medical person, extraordinary knowledge of the science, technology and protocols of adult stem cell therapy to bring the highest standards of safety, care and potential effectiveness to patients in need. A Nguyen, A et al Stromal vascular fraction: A regenerative reality? Part 1: Current concepts and review of the literature Journal of Plastic, Reconstructive & Aesthetic Surgery (2016) 69, 170e179 Guo et al Stromal vascular fraction: A regenerative reality? Part 2: Current concepts and review of the literature Journal of Plastic, Reconstructive & Aesthetic Surgery (2016) 69, 180e188 JK Fraser PhD and S Kesten MD Autologous Adipose Derived Regenerative Cells: A platform for therapeutic applications Advanced Wound Healing Surgical Technology International XXIX You can contact Feschbach via email or by phone: matt@ambrosecelltherapy.com (727) 743-1510

On this episode of Living Beyond 120, Mark and Dr. Gladden discuss thyroid function and disfunction. The thyroid is a hormone gland in the body that is under the control of the brain, determining the metabolic rate of a cell, through hormone production. One of those things this process does is help the mitochondria put out more ATP, which is "the currency of life." They discuss hypo- and hyperthyroidism, plus some other conditions, and some of the potentially far-reaching health consequences of when one's thyroid doesn't function properly. They consider some of the symptoms that people suffer when people have hypothyroidism, even if common medical tests do not recognize it. Dr. Gladden recommends what people can do to get a more accurate picture of their thyroid health.

On this episode, Mark and Dr. Gladden talk about autoimmune disorders, what they are and what can be done to help manage them. Dr. Gladden describes what a leaky immune system can do in your body. He discusses some of the common treatments for autoimmune diseases and the problems that can occur with certain medical interventions. They consider what you can do to help "seal the borders" of your digestive tract, protecting yourself from things that can breach the boundaries. They offer advice about decreasing exposure to environmental pollutants, reducing stress, eating a better diet for you, and healing from systemic attacks. With autoimmune disorders, boosting one's immune system can be problematic. Balancing it is the better goal. Dr. Gladden lists a number of possible supplements and peptides that could be used to help maintain a better balance.

Mark and Dr. Gladden invite Dr. Dale Bredesen on the podcast to speak about the science of cognitive decline and its prevention. Dr. Bredesen is an expert on neurodegenerative diseases, and he discusses multiple risk factors for Alzheimer's and dementia, including those both genetic and environmental. They examine crucial things you should do in your routine and environment to help reduce the risks that contribute to cognitive decline. Mark and Dr. Gladden review a number of advances in longevity research, considering the impact they might have on improved cognitive function. About the guest: Dale E. Bredesen, M.D., UCLA and Buck Institute Professor, Department of Molecular and Medical Pharmacology David Geffen School of Medicine at UCLA, Los Angeles, CA Founding President and CEO, Professor Emeritus, Buck Institute for Research on Aging, Novato, CA Dr. Bredesen received his undergraduate degree from Caltech and his medical degree from Duke. He served as Resident and Chief Resident in Neurology at UCSF, then was postdoctoral fellow in the laboratory of Nobel laureate Prof. Stanley Prusiner. He was a faculty member at UCLA from 1989-1994, then was recruited by the Burnham Institute to direct the Program on Aging. In 1998 he became the Founding President and CEO of the Buck Institute for Research on Aging, and Adjunct Professor at UCSF; then in 2013 he returned to UCLA as the Director of the Easton Center for Alzheimer's Disease Research. The Bredesen Laboratory studies basic mechanisms underlying the neurodegenerative process, and the translation of this knowledge into effective therapeutics for Alzheimer's disease and other neurodegenerative conditions, leading to the publication of over 220 research papers. He established the ADDN (Alzheimer's Drug Development Network) with Dr. Varghese John in 2008, leading to the identification of new classes of therapeutics for Alzheimer's disease. He and his group developed a new approach to the treatment of Alzheimer's disease, and this approach led to the discovery of subtypes of Alzheimer's disease, followed by the first description of reversal of symptoms in patients with MCI and Alzheimer's disease, with the ReCODE (reversal of cognitive decline) protocol, published in 2014, 2016, and 2018. His book, The End of Alzheimer's, is a New York Times Bestseller. Visit his website, https://www.ahnphealth.com/dr-bredesen.html. Follow him on Facebook here: https://www.facebook.com/drdalebredesen/

Mark and Dr. Gladden invite Ariel Garten to discuss the neuroscience behind Muse™, an EEG device that uses advanced signal processing to interpret your mental activity to help guide you toward better focus in meditation. Ariel is a co-founder of InteraXon Inc., the company that makes the device. On the show, they discuss how meditation and focus can help improve your overall life and health. They talk about how the brain is instrumental in being able to achieve peak performance and fight aging (or, in the reverse, hold you back or cause you to age faster). Ariel discusses her own meditation practice, as well as the other habits she uses to promote her own health and performance, including a healthy diet, exercise and social connection. Special Guest: Ariel Garten is a Canadian artist, scientist and intellectual. She was an avant garde clothing designer with a store called Flavour Hall (now closed) in Toronto, Ontario, Canada. She is deemed to have made a "significant contribution to the field" for her work in integrating art and science. She is pursuing cutting edge art and performances in other media, including dance, music, percussion, and cutting-edge instruments (such as hydraulophone, quintephone, and other). She creates work that explores the intersection of art and neuroscience. Garten lectures about interdisciplinary neuroscience topics, such as "The Neuroscience of Morals" (on TVO's Big Ideas televised lecture series), "The Neuroscience of Molecular Gastronomy," as well as psychotherapy and mental health. Garten is co-founder (with Trevor Coleman) and Chief Executive Officer of InteraXon, a Canadian company specializing in software for Non-invasive Brain-computer interfaces. Garten is also a psychotherapist trained in Neuro-linguistic programming. She has performed in many venues, including The Power Plant, and shown at the Art Gallery of Ontario and Banff Center for the Arts and sold her fashion across North America, including Holt Renfrew in Toronto, and lectured in North America and Europe. Learn more about Muse™ here: https://choosemuse.com/ Follow Ariel on Twitter: @ariel_garten.

On this episode, Mark and Dr. Gladden turn the tables, and Mark is the expert on hypnosis. They discuss how hypnosis actually works in the brain to unlock the resources that already exist for you. They discuss what types of issues hypnosis can help solve for people, and Mark walks through some examples of guiding a person through therapeutic hypnosis. He talks about PTSD and neuro-associations, explaining how trauma is linked to certain events and how hypnosis could help break free from the connection. They discuss the implications of how much power one's brain has over a body, especially when hypnosis can make such an impact on both mental and physical states.

On this episode, Mark and Dr. Gladden discuss the digestive system and its part in the entire ecosystem of your body. Many people suffer from leaky gut syndrome, a condition where the intestines becoming increasingly permeable and bacteria and other toxins can spread into the body. Also, a number of physical and mental conditions are often linked to excessive inflammation that starts in the digestive tract. They explore some of the symptoms that people can suffer because of failing digestive health, or from eating a diet that causes their GI tract distress. They talk about how to identify and eliminate what foods might be causing problems, as well as what foods and supplements you can add to start healing your digestive tract. Dr. Gladden explains the role of bacteria in our digestive system. He describes the difference between prebiotics and probiotics, and they discuss the overuse of antibiotics and antibacterial agents in our culture.

Mark and Dr. Gladden open the show discussing some of Mark's health and fitness progress, and they touch on how to safely obtain and use peptides. Next, they invite Dr. Kevin Wacasey onto the show. After a background in emergency room care, Dr. Wacasey opened a direct patient care (also called direct primary care) practice in 2013. He started this in reaction to seeing his patients paying massive amounts for basic care, because of their insurance. They discuss a number of issues related to our "sick care system" that exists in the U.S., calling for an end to the managed care model. They talk about the independent healthcare mindset and how patients need to be educated about what they're actually paying for. As insurance dictates what tests or procedures you can or cannot get, you may be denied the care you really want. Our current insurance system is profit-driven, not outcome-driven or patient focused. To be at our best health and performance, we must take control of our own health care. Special Guest: Dr. Kevin Wacasey Kevin Wacasey studied at the University of Texas at Arlington and fulfilled his residency in Emergency Medicine at Orlando Regional Medical Center. Kevin has held a certification from the American Board of Emergency Medicine since 1999. Dr. Wacasey has published two books focusing on health insurance and healthcare. His first book called The Guide to Buying Health Insurance, and Health Carewas published in 2016 and second called Healthcareonomics – 1,000 Crazy Ways American Health Insurance Controls America's Health Carewas published a year later in 2017. To go along with his two publications, Dr. Wacasey also has a blog and YouTube Channel that he contributes to regularly. Both the blog and YouTube Channel are called "Healthcareonomics". Currently, Dr. Wacasey is the attending physician and owner of Concierge Medical Practice in Fort Worth, Texas. Connect with Dr. Kevin Wacasey: Website: healthcareonomics.com; health-best.com Facebook: facebook.com/Healthcareonomics LinkedIn: linkedin.com/kevinwacaseymd Twitter: @Hconomics YouTube: https://www.youtube.com/channel

On this episode, Dr. Gladden and Mark welcome Dr. Jeff Spencer on the show to discuss his experiences and insights about setting and achieving goals. As an Olympian, sports scientist, author, doctor, artist and advisor to many high-profile business clients, he has developed a proven roadmap to help himself and others tackle challenges and win in life. They have an extensive conversation about the mindset needed to succeed, applying these lessons to winning in a variety of situations – including achieving longevity. Special Guest: Dr. Jeff Spencer makes winning BIG the normal for his clients. He knows how because he's been there – Olympian, sports scientist, artist, author, doctor, father and advisor to many of this era's most prolific achievers. Using his Goal Positioning System™ he has helped athletes win 40+ Olympic, World, National, and Tour de France gold medals; entrepreneurs and businesses grow exponentially and thought leaders moved to next level. His clients include Hitachi, Nike, Bulletproof and the rock band U2. Here's what people say about Jeff: "Enables the impossible", "My secret weapon", "Beyond, coach, mentor, or expert…Cornerman". Dr. Jeff has appeared in Fortune Magazine, GQ, and the Huffington Post. His most important achievement is the adoption of his daughter from rural Colombia at age 10. Learn more at https://www.drjeffspencer.com/and contact him at jeff@drjeffspencer.com.