Modern Healthspan

Here Prof Kaeberlein talks about the million molecule challenge and why he thought that it was necessary. Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He has published more than 200 scientific papers, has been recognized by several prestigious awards, and has Fellow status in the American Association for the Advancement of Science (AAAS), the American Aging Association, and the Gerontological Society of America (GSA). Dr. Kaeberlein is currently the CEO of the American Aging Association and has served on the Board of Directors for the Federation of American Societies for Experimental Biology (FASEB), AGE, and GSA. Dr. Kaeberlein is the founding Director of the UW Healthy Aging and Longevity Research Institute, the Director of the UW Nathan Shock Center of Excellence in the Basic Biology of Aging, Director of the Biological Mechanisms of Healthy Aging Training Program, and founder and co-Director of the Dog Aging Project. 🌐Links in this video Dog Aging Project https://dogagingproject.org/ Evaluation of off-label rapamycin use to promote healthspan in 333 adults https://pubmed.ncbi.nlm.nih.gov/37191826/ Catch us on YouTube: https://www.youtube.com/c/modernhealthspan 10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5 10% off DoNotAge all products with discount code MHS https://donotage.org/products/ ProHealth 15% of all products Code MODERN: https://www.prohealth.com/

Here Prof Kaeberlein talks about the Dog Aging Project a study which is following 100,000's of dogs to understand aging better and includes a RTC of rapamycin related to lifespan. Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He has published more than 200 scientific papers, has been recognized by several prestigious awards, and has Fellow status in the American Association for the Advancement of Science (AAAS), the American Aging Association, and the Gerontological Society of America (GSA). Dr. Kaeberlein is currently the CEO of the American Aging Association and has served on the Board of Directors for the Federation of American Societies for Experimental Biology (FASEB), AGE, and GSA. Dr. Kaeberlein is the founding Director of the UW Healthy Aging and Longevity Research Institute, the Director of the UW Nathan Shock Center of Excellence in the Basic Biology of Aging, Director of the Biological Mechanisms of Healthy Aging Training Program, and founder and co-Director of the Dog Aging Project. 🌐Links in this video Dog Aging Project https://dogagingproject.org/ Evaluation of off-label rapamycin use to promote healthspan in 333 adults https://pubmed.ncbi.nlm.nih.gov/37191826/ Catch us on YouTube: https://www.youtube.com/c/modernhealthspan 10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5 10% off DoNotAge all products with discount code MHS https://donotage.org/products/ ProHealth 15% of all products Code MODERN: https://www.prohealth.com/

Here Prof Kaeberlein talks about the recent paper on taurine deficiency as a driver of aging and makes some comparisons between taurine and rapamycin. Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He has published more than 200 scientific papers, has been recognized by several prestigious awards, and has Fellow status in the American Association for the Advancement of Science (AAAS), the American Aging Association, and the Gerontological Society of America (GSA). Dr. Kaeberlein is currently the CEO of the American Aging Association and has served on the Board of Directors for the Federation of American Societies for Experimental Biology (FASEB), AGE, and GSA. Dr. Kaeberlein is the founding Director of the UW Healthy Aging and Longevity Research Institute, the Director of the UW Nathan Shock Center of Excellence in the Basic Biology of Aging, Director of the Biological Mechanisms of Healthy Aging Training Program, and founder and co-Director of the Dog Aging Project. 🌐Links in this video Dog Aging Project https://dogagingproject.org/ Evaluation of off-label rapamycin use to promote healthspan in 333 adults https://pubmed.ncbi.nlm.nih.gov/37191826/ Catch us on YouTube: https://www.youtube.com/c/modernhealthspan 10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5 10% off DoNotAge all products with discount code MHS https://donotage.org/products/ ProHealth 15% of all products Code MODERN: https://www.prohealth.com/

Here Prof Kaeberlein provides some updates on rapamycin, in particular the results from the survey based trial that his team ran and thoughts on next steps for the supplement. Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He has published more than 200 scientific papers, has been recognized by several prestigious awards, and has Fellow status in the American Association for the Advancement of Science (AAAS), the American Aging Association, and the Gerontological Society of America (GSA). Dr. Kaeberlein is currently the CEO of the American Aging Association and has served on the Board of Directors for the Federation of American Societies for Experimental Biology (FASEB), AGE, and GSA. Dr. Kaeberlein is the founding Director of the UW Healthy Aging and Longevity Research Institute, the Director of the UW Nathan Shock Center of Excellence in the Basic Biology of Aging, Director of the Biological Mechanisms of Healthy Aging Training Program, and founder and co-Director of the Dog Aging Project. 🌐Links in this video Dog Aging Project https://dogagingproject.org/ Evaluation of off-label rapamycin use to promote healthspan in 333 adults https://pubmed.ncbi.nlm.nih.gov/37191826/ Catch us on YouTube: https://www.youtube.com/c/modernhealthspan 10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5 10% off DoNotAge all products with discount code MHS https://donotage.org/products/ ProHealth 15% of all products Code MODERN: https://www.prohealth.com/

Here we discuss how to measure your gut microbiome, what the future of probiotic and gut microbiome research may hold and what Dr Cutcliffe's personal regimen is. 🌐Links in this video Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the senior manager of biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals. Colleen completed her postdoctoral studies at Northwestern’s Children’s Memorial Hospital. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College. Catch us on YouTube: https://www.youtube.com/c/modernhealthspan Pendulum 20% discount with code HEALTHSPAN Akkermansia https://www.dpbolvw.net/click-100875787-15048681 Glucose Control https://www.tkqlhce.com/click-100875787-15009432 10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5 10% off DoNotAge all products with discount code MHS https://donotage.org/products/ ProHealth 15% of all products Code MODERN: https://www.prohealth.com/

Metabolic Daily is a less potent but more available form of the Glucose Control probiotic used in the clinical trial. Dr Colleen Cutcliffe discusses the differences in the formulations, the best time to take and what effects people have seen 🌐Links in this video Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the senior manager of biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals. Colleen completed her postdoctoral studies at Northwestern’s Children’s Memorial Hospital. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College. Catch us on YouTube: https://www.youtube.com/c/modernhealthspan Pendulum 20% discount with code HEALTHSPAN Akkermansia https://www.dpbolvw.net/click-100875787-15048681 Glucose Control https://www.tkqlhce.com/click-100875787-15009432 10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5 10% off DoNotAge all products with discount code MHS https://donotage.org/products/ ProHealth 15% of all products Code MODERN: https://www.prohealth.com/

We talk to Dr Colleen Cutcliffe about a clinical trial that they ran with 5 strains of probiotic. We also talk about whether the strains remained resident and what are the best prebiotics for akkermansia. 🌐Links in this video Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the senior manager of biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals. Colleen completed her postdoctoral studies at Northwestern’s Children’s Memorial Hospital. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College. Catch us on YouTube: https://www.youtube.com/c/modernhealthspan Pendulum 20% discount with code HEALTHSPAN Akkermansia https://www.dpbolvw.net/click-100875787-15048681 Glucose Control https://www.tkqlhce.com/click-100875787-15009432 10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5 10% off DoNotAge all products with discount code MHS https://donotage.org/products/ ProHealth 15% of all products Code MODERN: https://www.prohealth.com

Dr Colleen Cutcliffe, a co-founder of Pendulum, discusses the importance of Akkermansia muciniphila in gut health and disease prevention. She explains the role of this keystone strain in maintaining the gut lining and ongoing research on its regulation. Furthermore, she explores how Akkermansia promotes mucus production, regulates glucose control through GLP one stimulation, aids in weight loss, and metabolizes fiber into butyrate.

This is a bonus extra where we asked Dr Baur for his view on the recent taurine longevity paper as he had written a perspective piece in the same publication - Taurine linked with healthy aging ⁠https://www.science.org/doi/10.1126/science.adi3025⁠ 🌐Links in this video The Baur Lab website https://www.med.upenn.edu/baurlab/ Catch us on YouTube 10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5 10% off DoNotAge all products with discount code MHS https://donotage.org/products/ ProHealth 15% of all products Code MODERN: https://www.prohealth.com/

We talk to Dr Joseph Baur about NMNH and NRH and some of the ways that his lab is working on optimizing NAD boosters by trying to get more of the NAD into the mitochondria and testing on larger animals and in humans. 🌐Links in this video The Baur Lab website https://www.med.upenn.edu/baurlab/ Catch us on YouTube: https://www.youtube.com/c/modernhealthspan 10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5 10% off DoNotAge all products with discount code MHS https://donotage.org/products/ ProHealth 15% of all products Code MODERN: https://www.prohealth.com/