OPENPediatrics

This video is a part of our Pain Series. In this video, Drs. William Zempsky, Amanda Brandow, and Patricia Kavanagh outline major challenges in the treatment of sickle cell disease and the management of associated pain symptoms. They contrast the differences between acute and chronic pain associated with sickle cell disease and apply understandings of the disease in the context of case studies. The Pain Series is funded through the generosity of the MAYDAY Fund, which has, over the years, supported investigators and projects that have dramatically improved the pain management of children throughout the world. LEARNING OBJECTIVES By the end of this podcast, learners will be able to: • Gain an understanding of the mechanism of vaso-occlusion in sickle cell disease • Recognize key features of the emergency management of pain in sickle cell disease • Compare and contrast acute and chronic sickle cell pain • Gain insight into new forms of treatment for acute and chronic pain in sickle cell disease SPEAKERS William T. Zempsky, MD The Francine L. and Robert B. Goldfarb Endowed Chair for Pain and Palliative Medicine Associate Chair for Research Connecticut Children's Medical Center Professor of Pediatrics and Nursing University of Connecticut Amanda Brandow, DO, MS Professor of Pediatrics Section of Hematology/Oncology/Bone Marrow Transplantation Medical College of Wisconsin Children’s Wisconsin Patricia Kavanagh, MD Attending Physician, Pediatric Emergency Department Boston Medical Center Associate Professor of Pediatrics Boston University School of Medicine DATES Initial publication: August 24, 2020 CITATION Brandow A, Kavanagh P, Zackin B, Rettig J, Zempsky W. Managing Pain in Sickle Cell Disease: Challenges and Opportunities. 8/2020. Online Video. OPENPediatrics. https://learn.openpediatrics.org/learn/course/internal/view/elearning/4753/managing-pain-in-sickle-cell-disease-challenges-and-opportunities.

This special version of the World Shared Practice Forum features speakers from the monthly International PICU COVID-19 Collaborative meeting hosted by Dr. Jeffrey Burns. This is a cutting-edge worldwide online collaboration in which the latest knowledge and best practices relating to COVID-19 are shared among front-line clinicians in real-time. In this session from August 1, 2020, Dr. Michael Mina outlines the most current COVID-19 testing strategies, best practices for disease surveillance, and greater disease control in the future. He weighs the pros and cons of multiple approaches to disease surveillance, as well as how variables like testing costs may affect future policy decisions and large-scale efforts. The second portion of the PICU COVID-19 International Collaborative focuses on the pediatric scope of COVID-19 and discusses evidence-based therapies and guidelines. This was jointly prepared by Drs. Kathleen Chiotos, Daniele Dona, Julie Fitzgerald, Gang Liu, and Mari Nakamura.

Listen as Dr. Kusum Menon discusses the history and science behind corticosteroids and their use in septic shock. She covers the pathophysiology of adrenal function, identifies potential risks and benefits of empiric corticosteroid treatment, and outlines an approach to corticosteroid use in septic shock in children. Initial publication: June 19, 2020. Please visit: www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu Please note: OPENPediatrics does not support nor control any related videos in the sidebar, these are placed by Youtube. We apologize for any inconvenience this may cause.

This episode is an international collaborative conference call hosted by Dr. Jeffrey Burns of Boston Children's Hospital and Harvard Medical School. Featured speakers are Drs. Daniel Barouch, Trevor Duke, and Robinder Khemani, who outline current vaccine developments, oxygen therapy, and ventilation guidelines (respectively) in the time of COVID-19. Initial publication: May 22, 2020. OPENPediatrics attempts to keep all COVID-19 information as accurate and up to date as possible. However, as recommendations for care and treatment are rapidly changing due to the nature of the pandemic, Boston Children's Hospital does not assume any legal liability or responsibility for the accuracy, completeness or usefulness of any information on OPENPediatrics. We advise users to please pay close attention to the publication date of all COVID-19 content, and always adhere to your institution’s specific policies and guidelines. Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user.For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu

Dr. Karen Choong, Professor of Pediatrics at McMaster University, speaks on how to implement early mobilization in critically ill children. She outlines goals for early mobilization, defines criteria for implementation, and offers tips about how to effectively achieve this in the PICU. Initial publication: April 24, 2020. Please visit: www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu

Listen as Dr. Louise Jakubik discusses mentorship, how it benefits the field of nursing and discusses the development of the Jakubik Mentoring Model. Initial publication: April 17, 2020. Please visit: www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu

Listen as Drs. Scot Bateman and Stacey Valentine of Umass Memorial Medical Center, discuss current red blood cell (RBC) transfusion practices in critically ill children, outline an approach of creating consensus and guidance of clinical RBC transfusion practice, and present recommendations from the Transfusion and Anemia Expertise Initiative. Please visit: www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu

Listen as Dr. Nadir Yehya, Assistant Professor of Anesthesiology and Critical Care Medicine at the Children's Hospital of Philadelphia and the University of Pennsylvania, discusses the advantages and disadvantages of biomarkers in critical care research. He covers the specifics of how biomarkers influence endotyping, subphenotyping, and enrichment for critical care trials (with a focus on sepsis and ARDS). He also provides an overview of existing literature in adult and pediatric sepsis and ARDS, as well as the strengths and weaknesses of using biomarkers in research. Initial publication: February 21, 2020. Please visit: www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu

In this chapter of the Rwandan National Neonatal Protocol, Dr. Aicha Uwamahoro explains the etiology, investigation and treatments for anemia, bleeding, and polycythemia in the neonatal context. Initial publication: February 14, 2020. Please visit: www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu

In this chapter of the Rwandan National Neonatal Protocol, Dr. Hippolyte Bwiza-Muhire discusses risk factors for hyperbilirubinemia in full term and premature infants, how to assess hyperbilirubinemia on a physical exam and how to initiate laboratory testing to determine, initiate, and manage appropriate treatment for hyperbilirubinemia in the neonate. Initial publication: February 12, 2020. Please visit: www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu