Peptides and Longevity: Redefining Aging and Transforming Health with Dr. Kent Holtorf

In this episode of Peptides & Longevity, Dr. Kent Holtorf speaks with Dr. Sanjeev Goel, a Toronto-based biohacker and longevity expert. They explore how psychedelics, peptides, and data-driven therapies are transforming health, performance, and aging—revealing what’s next in the science of self-optimization.Born in Montreal and now based in Toronto, Dr. Goel’s journey has been far from conventional. With over five decades of lived experience and a résumé that spans remote medical service in Himalayan villages to teaching mindfulness to healthcare professionals, his voice carries both wisdom and credibility. His biological age is a full ten years younger than his chronological one, a living testament to the anti-aging practices he preaches. But his path hasn’t been without hardship. In 2019, a severe Lyme-like illness brought him face-to-face with his own mortality. The experience sparked a deeper commitment to healing, self-exploration, and science-backed rejuvenation.Sanjeev Goel, MDWebsite: https://www.sanjeevgoel.com/ YouTube: https://www.youtube.com/channel/UCVLk0UmBqWSiUU3SFKrFtig Instagram: https://www.instagram.com/drsanjeevgoel Facebook: https://www.facebook.com/drsanjeevgoel/ ----Holtorf Medical GroupWebsite: ⁠⁠⁠⁠⁠⁠⁠⁠https://holtorfmed.com/⁠⁠⁠⁠⁠⁠⁠⁠Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠⁠⁠⁠⁠⁠Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/holtorfmedicalgroup/⁠⁠⁠⁠⁠⁠⁠⁠----Kent Holtorf, MDYouTube: ⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠⁠⁠⁠⁠⁠----Produced by DrTalks⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠

Valerie Phillips, ND — a naturopathic doctor blending biochemistry and integrative hormone care — walks through restoring libido by rebalancing hormones, improving sleep, calming stress, healing gut and pelvic floor, and where peptides like PT-141 and sleep peptides fit in. Short strategic shifts, targeted testing, and pelvic floor work are highlighted as pathways back to vitality and connection.

The secret to living better for longer starts with removing the cells that make you old. In this episode of Peptides and Longevity, Dr. Joe Cleaver pulls back the curtain on senolytics, showing how to clear senescent cells and build you back up with mitochondria, hormones, and targeted peptides.Want to age in reverse? Start by clearing out the cells making you old. In this episode of Peptides and Longevity, Dr. Joe Cleaver reframes longevity around one simple idea, which is that you remove what ages you and then rebuild what keeps you young. He explains how senescent cells accumulate, why they become inflammatory factories, and how fasting and senolytics can clear the backlog. He then shows how to protect and upgrade mitochondria, why telomeres work as a useful marker rather than a destiny, and where peptides belong. The result is a stepwise, precision plan that starts with clearance, moves into cellular energy, and finishes with targeted repair for brain, skin, hair, and whole-body performance. Watch the full episode now and learn how to start clearing the cells that make you old.Dr. Joseph Cleaver is a board-certified internist and fellow in anti-aging and metabolic medicine who blends preventive lifestyle medicine, regenerative therapeutics, and peptide science. He teaches clinicians nationwide and sees patients through the Paradigm Wellness Medical Group. He also hosts small-group masterminds on longevity and regenerative medicine at his winery in Sonoma.Dr. Joseph CleaverWebsite: www.pwmgmed.comIntegrative PeptidesWebsite: ⁠⁠⁠⁠⁠⁠https://integrativepeptides.com/⁠⁠⁠⁠⁠⁠Facebook: ⁠⁠⁠⁠⁠⁠https://www.facebook.com/integrativepeptidesofficial/⁠⁠⁠⁠⁠⁠Instagram: ⁠⁠⁠⁠⁠⁠https://www.instagram.com/integrativepeptides/⁠⁠⁠⁠⁠⁠----Holtorf Medical GroupWebsite: ⁠⁠⁠⁠⁠⁠https://holtorfmed.com/⁠⁠⁠⁠⁠⁠Facebook: ⁠⁠⁠⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠⁠⁠⁠Instagram: ⁠⁠⁠⁠⁠⁠https://www.instagram.com/holtorfmedicalgroup/⁠⁠⁠⁠⁠⁠----Kent Holtorf, MDYouTube: ⁠⁠⁠⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠⁠⁠⁠----Produced by DrTalks⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠

Tried everything and still sick? This protocol could finally move the needle. In this episode of Peptides and Longevity, Dr. Gordon Crozier reveals how he helped patients with complex chronic conditions recover using specific peptides paired with ozone, amino acid therapy, and detoxification strategies that reset the body from the inside out.What happens when even the top hospitals can’t help? In this episode of Peptides and Longevity, Dr. Gordon Crozier discusses how he takes on the ‘sick of the sick’ using a cellular approach that rebuilds health from the inside out. He delves into how he combines peptides with ozone, amino acid therapy, and phosphatidylcholine to help calm neuroinflammation and restore balance where medicine left off. Dr. Crozier also reveals why advanced tests often tell the story traditional tests miss—and how timing, pulsing, and persistence turn short-term improvements into lasting recovery.Dr. Gordon Crozier is the owner and medical director of Crozier Clinic, a leading genetics-based center specializing in peptides, hormone optimization, and advanced diagnostics. A former neurology and neurosurgery clinician, he combines deep neurological insight with personalized, regenerative protocols.As a faculty member and peptide educator for A4M and the International Peptide Society, he has trained hundreds of practitioners nationwide. He’s also the author of Healing One Cell at a Time, Ticked Off, and Heal Your Cells. Save Your Life., and continues to pioneer innovative, compassionate care in chronic illness and longevity medicine.-----Dr. Gordon CrozierWebsite: www.crozierclinic.comInstagram: www.instagram.com/drgordoncrozierFacebook: www.facebook.com/DrCrozierIntegrative PeptidesWebsite: ⁠⁠⁠⁠⁠https://integrativepeptides.com/⁠⁠⁠⁠⁠Facebook: ⁠⁠⁠⁠⁠https://www.facebook.com/integrativepeptidesofficial/⁠⁠⁠⁠⁠Instagram: ⁠⁠⁠⁠⁠https://www.instagram.com/integrativepeptides/⁠⁠⁠⁠⁠----Holtorf Medical GroupWebsite: ⁠⁠⁠⁠⁠https://holtorfmed.com/⁠⁠⁠⁠⁠Facebook: ⁠⁠⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠⁠⁠Instagram: ⁠⁠⁠⁠⁠https://www.instagram.com/holtorfmedicalgroup/⁠⁠⁠⁠⁠----Kent Holtorf, MDYouTube: ⁠⁠⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠⁠⁠----Produced by DrTalks⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠

Christopher Wakely, ND, a naturopath who treats complex chronic illness including tick‑borne and mold-related conditions, shares a clear roadmap for patients. He talks about opening detox pathways, sequencing care from drainage to immune retraining, and when to add peptides, ozone, and neural therapies. Short, practical guidance on simple labs, drainage tools, and pediatric strategies for PANS/PANDAS is highlighted.

Kelly Halderman, physician and clinical nutritionist who built the Metabolic Code after recovering from chronic Lyme, explains how to decode your unique biochemistry into five TRIADS. She describes using targeted questionnaires plus labs to prioritize detox, fix bile flow, and stop protocols from stalling. Clear maps and tracking turn scattered data into actionable starting points for real progress.

Leaky gut isn’t just about digestion—it’s also messing with your brain. In this episode of Peptides and Longevity, Kiran Krishnan, a research microbiologist, breaks down the gut–brain connection and why a leaky gut can fuel inflammation, brain fog, and mood issues. He also reveals groundbreaking research on spore-based probiotics—how they repair the gut lining, calm inflammation, and may even help reprogram metabolism for better energy and body composition.-----A mass extinction is happening inside your gut—and it’s fueling everything from brain fog to autoimmunity. In this episode of Peptides and Longevity, Kiran Krishnan explains why the microbiome is not just trillions of organisms, but a vast genetic toolkit that powers most of our body’s chemistry. He warns that modern living is driving a ‘mass extinction’ of gut species, weakening immune training, fueling leaky gut, and setting the stage for allergies, autoimmunity, and chronic illness.Krishnan then connects the dots to the brain, showing how toxins from a leaky gut trigger inflammation, brain fog, mood issues, and even neurodegeneration. He shares evidence on how spore-based probiotics restore gut diversity, strengthen keystone species, repair the gut barrier, and lower inflammatory markers—sometimes in as little as a month. Krishnan also highlights a pilot study where spores and prebiotics reduced visceral fat and improved insulin health without diet changes, pointing to true ‘metabolic reprogramming.’ He wraps up with a reality check on overhyped probiotics and testing, urging a smarter, science-based approach to gut health.-----Kiran Krishnan is a research microbiologist with over two decades of experience in the field of nutrition and supplements. Trained in molecular medicine and microbiology at the University of Iowa, he went on to hold leadership roles in global product development before becoming General Manager of Novozymes One Health America, Microbiome Labs. A sought-after speaker at medical and nutrition conferences, he is known for making complex science on the human microbiome practical and accessible. He is actively involved in more than a dozen human clinical trials, serves on multiple scientific advisory boards, and holds peer-reviewed publications and global patents in probiotic and microbiome research.-----Kiran KrishnanWebsite: https://microbiomelabs.com/home/Instagram: https://www.instagram.com/kiranbiome/Facebook: https://www.facebook.com/kiran.krishnan.9279LinkedIn: https://www.linkedin.com/in/kiran-k-b302147/-----Integrative PeptidesWebsite: ⁠https://integrativepeptides.com/⁠Facebook: ⁠https://www.facebook.com/integrativepeptidesofficial/⁠Instagram: ⁠https://www.instagram.com/integrativepeptides/⁠----Holtorf Medical GroupWebsite: ⁠https://holtorfmed.com/⁠Facebook: ⁠https://www.facebook.com/holtorfmed/⁠Instagram: ⁠https://www.instagram.com/holtorfmedicalgroup/⁠----Kent Holtorf, MDYouTube: ⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠----Produced by DrTalks⁠https://drtalks.com/podcast-service/

Want to heal injuries faster, bounce back from surgery stronger, or even slow aging with your body’s own healing signals? In this episode of Peptides & Longevity, Dr. R. David Calvo reveals how he uses peptides and regenerative therapies to supercharge recovery, protect joints, and help patients feel decades younger.----Dr. R. David Calvo spent decades as a high-volume orthopedic surgeon before realizing that surgery alone wasn’t enough. So he began exploring regenerative medicine, using platelet-rich plasma, bone marrow, fat-derived stem cell products, and later peptides, to improve not just surgical outcomes, but overall vitality. What he discovered transformed both his patients’ results and his own health: by optimizing the “terrain” of the body, recovery accelerates and performance rebounds.In this episode of Peptides & Longevity, Dr. Calvo joins us to explain how he now uses targeted peptides alongside regenerative procedures to help patients heal faster, sleep better, and stay strong as they age. He also shares real-world cases of athletes bouncing back from injuries in record time, surgical wounds closing faster, and patients regaining energy and focus by supporting their mitochondria and hormones. His message is simple yet powerful: you don’t have to accept decline—if you give your body the right signals, it can repair itself.----Dr. R. David Calvo is a board-certified orthopedic surgeon and sports medicine expert with over three decades of experience caring for athletes from high school to professional levels. After decades in surgical practice, he shifted his focus to preventative, regenerative, and anti-aging medicine—founding Texas Center Wellness in Austin, Texas.Trained through the American Academy of Anti-Aging Medicine and the Age Management Medicine Group, Dr. Calvo now helps patients worldwide through telemedicine, using cutting-edge therapies like peptides, stem cells, exosomes, platelet-rich plasma, and bioidentical hormones to accelerate healing, enhance longevity, and optimize human performance.----R. David Calvo, MDWebsite: https://texascenterwellness.com/LinkedIn: https://www.linkedin.com/in/dr-david-calvo-698b541a/----Integrative PeptidesWebsite: https://integrativepeptides.com/Facebook: https://www.facebook.com/integrativepeptidesofficial/Instagram: https://www.instagram.com/integrativepeptides/----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalks  https://drtalks.com/podcast-service/

Dr. Cory Tichauer, naturopathic physician and founder of Bear Creek Naturopathic Clinic, treats complex biotoxin and chronic infectious illnesses. He explains how mold, metals, solvents and hidden infections interact to drive chronic inflammation. He outlines testing pitfalls, binder and detox strategies, and how targeted peptides can calm inflammation and support recovery.

Paul Barattiero, entrepreneur and researcher who founded Echo Water to bring molecular hydrogen therapies to patients. He recounts discovering hydrogen water’s clinical potential and discusses how dissolved hydrogen acts as a selective antioxidant, its effects on mitochondria and telomeres, links to gut fermentation and microbiome health, dosing like natural gut production, and practical delivery options.