Peptides and Longevity: Redefining Aging and Transforming Health with Dr. Kent Holtorf

Perimenopause can feel like your body and emotions have suddenly turned against you. In this episode of Peptides and Longevity, Dr. Jen Pfleghaar explains why progesterone declines first, why estrogen becomes erratic, and how stress, toxins, and insulin resistance can drive anxiety, weight gain, libido changes, and skin issues years before menopause.Jen Pfleghaar, DO, ABOIMWebsite: pflegmed.com/dr-jenInstagram: instagram.com/integrativedrmomLinkedIn: linkedin.com/in/drjenpfleghaar/🎧 The Integrative Health Podcast with Dr. Jen  Explore the root causes of fatigue, hormone imbalance, and chronic illness—with a functional medicine doctor who helps patients take their health back:Listen on SpotifyListen on Apple PodcastsListen on BuzzsproutListen on iHeart RadioVisit ⁠⁠⁠⁠⁠⁠www.integrativepeptides.com⁠⁠⁠⁠⁠⁠ and use the code PODLIFE to get 10% off your first purchase.Holtorf Medical GroupWebsite: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://holtorfmed.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/holtorfmedicalgroup/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Kent Holtorf, MDYouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Produced by DrTalks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠

Dr. Jeffrey Gross, a spinal neurosurgeon turned regenerative medicine expert and founder of ReCELLebrate, explains how plant-derived exosomes act as nature’s delivery system. He contrasts powdered supplements with exosome-packed nutrients. Short, clear takes cover how these extracts are made, what Longevex does, dosing choices, and pairing with clinic therapies.

Trauma doesn’t stay in the past. It changes how your brain and immune system respond. In this episode of Peptides and Longevity, Dr. Keesha Ewers joins us to discuss the different kinds of trauma and how perceived stress can mirror brain changes in PTSD. We also dive into why healing requires shifting the patterns of your nervous system.Dr. Keesha Ewers is a board-certified functional and Ayurvedic medicine practitioner, trauma-informed psychotherapist, Doctor of Sexology, and integrative family nurse practitioner with over three decades of clinical experience. She is the founder and medical director of the Academy for Integrative Medicine Health Coach Certification Program and a MAPS-certified MDMA-assisted psychotherapy therapist.After leading the HURT Study on unresolved trauma, Dr. Ewers developed the HURT Model and Freedom Framework, approaches she used to reverse her own autoimmune disease and now applies with patients worldwide. She is a sought-after speaker, a TEDx presenter, and the best-selling author of Solving the Autoimmune Puzzle, The Quick and Easy Autoimmune Paleo Cookbook, and Your Libido Story.Dr. Keesha EwersWebsite: drkeesha.comInstagram: instagram.com/drkeeshaewersLinkedIn: linkedin.com/in/keeshaewersVisit ⁠⁠⁠⁠www.integrativepeptides.com⁠⁠⁠⁠ and use the code PODLIFE to get 10% off your first purchase.Holtorf Medical GroupWebsite: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://holtorfmed.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/holtorfmedicalgroup/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Kent Holtorf, MDYouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Produced by DrTalks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠

Most supplements fail not because they’re useless, but because they’re poorly made, underdosed, or mislabeled. In this episode of Peptides and Longevity, Dr. Kent Holtorf speaks with Don Wiencek about private-label supplements, quality control, FDA pitfalls, and how doctors can create effective, ethical formulations their patients can trust.Don Wiencek is the founder and owner of Tru Body Wellness, a private-label dietary supplement company that partners with healthcare practitioners to create high-quality, customized formulations. He brings decades of experience as a president, CEO, and executive in product manufacturing, with a background in engineering and a master’s degree in business.Don has focused on helping doctors navigate formulation challenges, manufacturing quality, regulatory compliance, and labeling accuracy—allowing practitioners to confidently bring effective supplements to their patients while building sustainable, ethical practices.Website: trubodywellness.com/LinkedIn: linkedin.com/in/donald-wiencek-4754b99/Visit ⁠⁠⁠www.integrativepeptides.com⁠⁠⁠ and use the code PODLIFE to get 10% off your first purchase.Holtorf Medical GroupWebsite: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://holtorfmed.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/holtorfmedicalgroup/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Kent Holtorf, MDYouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Produced by DrTalks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠

Gregory Kelly, ND, a naturopathic physician and product director at Neurohacker Collective, blends engineering smarts with two decades in nootropics and chronobiology. He discusses how brain energy and mitochondria shape focus. He explains Goldilocks dosing, caffeine’s narrow sweet spot, stacking strategies, and why timing and nutrients like choline matter for sustainable cognitive performance.

What if your concussion wasn’t just about the hit to your head, but everything that was already simmering in your body? In this episode of Peptides and Longevity, neurosurgeon and functional medicine practitioner Dr. Chad Prusmack joins us to unpack precision medicine, environmental subconcussion, and why toxins, infections, autonomic imbalance, and data-driven rehab can make or break brain recovery.----Dr. Chad Prusmack is a board-certified neurosurgeon and one of the only neurosurgeons in the United States to also hold a functional medicine certification. After years of operating in traditional neurosurgery, he saw too many patients whose scans looked ‘perfect’ but who were still suffering, which pushed him to integrate multi-omics, precision testing, and systems-level thinking into his practice.He is the founder of Resilience Code, a 45,000-square-foot health and performance center in Denver that blends neurosurgery, functional medicine, strength and conditioning, neurofeedback, and comprehensive rehab under one roof. As a primary neurosurgical consultant for the Denver Broncos and the United States Olympic Committee, he specializes in neurodegenerative disease, concussion, post-concussion syndrome, and performance medicine. His mission is to shine a high-definition light on the continuum between ‘healthy’ and ‘diseased,’ so patients can finally understand why they feel the way they do and what to do next.----Dr. Chad PrusmackWebsite: myresiliencecode.comWebsite: healthonephysiciangroup.com/physicians/profile/Dr-Chad-J-Prusmack-MDLinkedIn: linkedin.com/in/chad-prusmack-58552020----Visit ⁠www.integrativepeptides.com⁠ and use the code PODLIFE to get 10% off your first purchase.----Holtorf Medical GroupWebsite: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://holtorfmed.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/holtorfmedicalgroup/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----Kent Holtorf, MDYouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----Produced by DrTalks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠

What if your iron wasn’t just high but actively damaging your cells? In this episode of Peptides and Longevity, Bob Miller joins us to explore a little-known process called ferroptosis: a kind of ‘iron overload gone wrong’ that may help explain why some people get stuck in chronic illness. Bob breaks down how everyday exposures, stress, and hidden genetic patterns can overwhelm the body, and shares a fascinating case study showing how personalized insights can reveal why someone isn’t getting better.----Bob Miller is a certified traditional naturopath and a pioneer in the field of genetic-specific nutrition. For more than three decades, he has helped clients uncover how their gene variants influence detoxification, inflammation, and chronic symptoms, and how targeted nutritional support can make a life-changing difference. Bob is the founder of the Tree of Life practice, where he has spent decades connecting the dots between genetics, environment, and stubborn health issues.He is also the formulator behind more than 55 epigenetic nutritional products designed to support enzyme function and healthy detox pathways, widely used by health professionals across the country. As an educator, he teaches physicians and practitioners through national seminars, webinars, and his certification program in genetic nutrition. He also created the innovative MethylGenetic Nutritional Analysis™ software, which blends gene data, labs, and symptoms to craft personalized wellness protocols.Bob is the founder of the NutriGenetic Research Institute, where he leads groundbreaking studies on the relationship between genetic variants and complex conditions such as chronic Lyme disease, research that has been internationally recognized and awarded. His work continues to shape how practitioners understand genes, toxins, and individualized healing.----Bob Miller, CTNWebsite (NutriGenetic): nutrigeneticresearch.orgWebsite (Tree of Life): tolhealth.comLinkedIn: linkedin.com/in/bob-miller-ctn-a0b8021b----Visit www.integrativepeptides.com and use the code PODLIFE to get 10% off your first purchase.----Holtorf Medical GroupWebsite: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://holtorfmed.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/holtorfmedicalgroup/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----Kent Holtorf, MDYouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----Produced by DrTalks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠

PRP: miracle cure or medical myth? Here’s the real story. In this episode of Peptides and Longevity, Dr. Jeffrey Piccirillo reveals why some platelet-rich plasma treatments disappoint while others spark remarkable repair. He also breaks down the small tweaks that can turn an average treatment into a regenerative breakthrough. If you’ve ever wondered why this therapy seems magical for some and useless for others, this episode connects the dots.----Dr. Jeffrey Piccirillo is a board-certified orthopedic surgeon and the CEO and Founder of Regenerative Medical Associates in Florida. After stepping away from surgery due to hand tremors, he shifted his career toward holistic and regenerative medicine, opening The Center for Total Wellness in Iowa. There, he focused on restoring health through intravenous nutrition, targeted supplements, diet modification, and the early development of platelet-rich plasma and stem cell protocols for joint, tendon, and ligament injuries.Dr. Piccirillo began consulting with practices across the country, helping physicians transition from insurance-based models to thriving cash practices while delivering better patient outcomes. He and his team support hundreds of clinics nationwide, offering everything from regenerative products and equipment to hands-on training and marketing support. He also partners with leading innovators to train clinicians in platelet-rich plasma, joint injections, sexual wellness procedures, and other regenerative techniques, making his company a full-service resource for practitioners looking to excel in regenerative medicine.----Jeffrey Piccirillo, DOWebsite: regenmedicalgroup.com----Holtorf Medical GroupWebsite: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://holtorfmed.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/holtorfmedicalgroup/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----Kent Holtorf, MDYouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----Produced by DrTalks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠

The secret to healthier aging might be hiding in your chromosomes. In this episode of Peptides and Longevity, Eric McDonald of T.A. Sciences joins us to unpack how people are using their supplements to help preserve telomere length, support immune function, and promote healthier aging.----Eric McDonald brings almost four decades of experience in biology, pharmaceuticals, and regenerative medicine. After earning his biology degree from Michigan State University, he launched a highly successful pharmaceutical career with Parke-Davis, helping bring blockbuster drugs to the market like Lipitor, Lopid, and Cognex. He quickly rose through leadership roles in sales, training, and marketing before later serving as Director of Sales at both Doak Dermatologics and Taro Pharma.In 2013, Eric shifted his focus toward regenerative medicine, a move that reshaped his career and passion. He joined T.A. Sciences as Director of Sales, where he helped grow operations and worked closely with top experts in telomere biology. Today, he is known for bridging his pharmaceutical background with cutting-edge longevity science, helping clinicians and consumers better understand the tools that may support healthier aging.----Eric McDonaldWebsite: tasciences.comLinkedIn: linkedin.com/in/ericmcdonald ----Holtorf Medical GroupWebsite: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://holtorfmed.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/holtorfmedicalgroup/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----Kent Holtorf, MDYouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----Produced by DrTalks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠

Reversing autoimmunity isn’t about chasing perfect lab numbers. It’s about teaching your immune system how to find balance again. In this episode of Peptides and Longevity, Elizabeth Tringali joins us to reveal how small, strategic steps like the right peptides, detox support, and food choices can quiet flares, rebuild energy, and help you feel like yourself again.----Elizabeth Tringali is a Board-Certified Physician Assistant and a Diplomate of the American Academy of Anti-Aging Medicine. A graduate of the University of Florida, she began her career in nutrition science and research with the Women’s Health Initiative, an experience that shaped her lifelong passion for holistic, patient-centered care.Blending her roots in nutrition with advanced training in anti-aging and regenerative medicine, she has spent more than two decades helping patients uncover the root causes of fatigue, hormone imbalance, and autoimmune conditions. Known for combining natural therapies with cutting-edge medical innovations, she creates personalized healing plans that restore energy, balance, and long-term wellness.----Elizabeth Tringali, PA-CWebsite: tringali-health.comInstagram: instagram.com/etringaliFacebook: facebook.com/elizabeth.tringali.2025/LinkedIn: linkedin.com/in/elizabeth-tringali-pa-c-0010a523----Holtorf Medical GroupWebsite: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://holtorfmed.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/holtorfmedicalgroup/⁠⁠⁠⁠⁠⁠⁠⁠⁠----Kent Holtorf, MDYouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠⁠⁠⁠⁠⁠⁠----Produced by DrTalks⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠