Colloques du Collège de France - Collège de France

Virginie Courtier-OrgogozoBiodiversité et écosystèmes (2022-2023)Collège de FranceColloque - Integrating Evolutionary Genetics and Ecology : Microevolutionary Implications of Transposable Element-Mediated Variation in PlantsVincent Colot, ENS, Paris, France

Virginie Courtier-OrgogozoBiodiversité et écosystèmes (2022-2023)Collège de FranceColloque - Integrating Evolutionary Genetics and Ecology : Genomic Basis of Repeated Adaptation Varies with Divergence in ArabidopsisRepeated evolution tends to be more predictable. The impressive spectrum of recent reports on genomic parallelism, however, revealed that the fraction of the genome that evolves in parallel varies greatly, possibly reflecting different evolutionary scales investigated. Here, we demonstrate divergence-dependent parallelism using a comprehensive genome-wide dataset comprising 12 cases of parallel alpine adaptation and identify decreasing probability of adaptive re-use of genetic variation as the major underlying cause. This finding empirically demonstrates that evolutionary predictability is scale dependent and suggests that availability of preexisting variation drives parallelism within and among populations and species. Altogether, our results inform the ongoing discussion about the (un)predictability of evolution, relevant for applications in pest control, nature conservation, or the evolution of pathogen resistance.Magdalena BohutínskáI am interested in understanding the genomic basis of adaptive evolution. I study plant evolution after a dramatic mutation, whole genome duplication, and in challenging high alpine environments. I am especially interested in the mechanisms governing repeatability of adaptation.

Virginie Courtier-OrgogozoBiodiversité et écosystèmes (2022-2023)Collège de FranceColloque - Integrating Evolutionary Genetics and Ecology : Diversity and Evolution of Visual Systems in Frogs and ToadsOrganisms rely on their senses—touch, hearing, vision, smell—to interpret their surroundings to find food, avoid predators, find mates, regulate temperatures, and follow their circadian rhythms. These complex traits are fascinating to study because they are under strong selection and give us a glimpse as to how other organisms experience the world. Frogs are compelling models for investigating the diversity and evolution of sensory systems because they have adapted to live (and sense) in a wide variety of environments, from tropical rainforests to deserts, and underground (fossorial) to tree-dwelling (arboreal). While some species are active during the day, others come out at night. Some frogs are completely aquatic and of course, many frogs have a major transition in their development as they metamorphose from an aquatic tadpole to a terrestrial adult. In this seminar I will share some of our current research combining spectral, morphological and genomic approaches to understand how frog visual systems have evolved in response to different environmental and behavioral contexts.Rayna Camille Bell received her Ph.D. in Ecology and Evolutionary Biology from Cornell University in 2014, and was awarded a University of California Chancellor's Postdoctoral Fellowship in the Museum of Vertebrate Zoology at the University of California, Berkeley. In 2015, Rayna joined the National Museum of Natural History as Curator of Amphibians and Reptiles where she remains a research associate. In 2019, Rayna moved to the California Academy of Sciences where she is the Assistant Curator of Herpetology. Rayna's research focuses on the ecology and evolution of amphibians and reptiles with an emphasis on island biogeography, hybrid zones, and coloration phenotypes.

Virginie Courtier-OrgogozoBiodiversité et écosystèmes (2022-2023)Collège de FranceColloque - Integrating Evolutionary Genetics and Ecology : The Life and Work of Jean R. DavidAmir Yassin, EGCE, université Paris-Saclay, Gif-sur-Yvette, France

Virginie Courtier-OrgogozoBiodiversité et écosystèmes (2022-2023)Collège de FranceColloque - Integrating Evolutionary Genetics and Ecology : IntroductionVirginie Courtier-Orgogozo, directrice de recherche au CNRS, professeure associée à l'École polytechnique, professeure invitée du Collège de France

Hugues de ThéCollège de France - Année 2022-2023Oncologie cellulaire et moléculaireColloque - Revisited Chemotherapy : ConclusionsHugues de Thé

Hugues de ThéCollège de France - Année 2022-2023Oncologie cellulaire et moléculaireColloque - Revisited Chemotherapy : Revisiting Chemotherapy Failure—From a Senescence Point-of-viewClemens Schmitt, Hôpital de la Charité, Berlin, Allemagne

Hugues de ThéCollège de France - Année 2022-2023Oncologie cellulaire et moléculaireColloque - Revisited Chemotherapy : SUMOylation Controls Acute Myeloid Leukemias Response to (Chemo)therapiesGuillaume Bossis, IGMM, CNRS, Montpellier, France

Hugues de ThéCollège de France - Année 2022-2023Oncologie cellulaire et moléculaireColloque - Revisited Chemotherapy : Metabolic Bases of Responses to Chemotherapy in LeukemiaJean-Emmanuel Sarry, INSERM, Toulouse, France

Hugues de ThéCollège de France - Année 2022-2023Oncologie cellulaire et moléculaireColloque - Revisited Chemotherapy : Killing Cancer by DNA Damage Through Synthetic LethalityThomas Helleday, Karolinska Institutet, Stockholm, Suède