Mind & Matter

Nick Jikomes
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Mar 2, 2022 • 2h 38min

Consciousness, Dissociation, Metacognition, Idealism, Materialism, Philosophy, Psychedelics, Death & Mind | Bernardo Kastrup | 60

Send us Fan MailNick talks to computer scientist and philosopher Bernardo Kastrup about various topics related to consciousness and the nature of reality. They discuss: psychological dissociation; the scientific study of 'neural correlates of consciousness'; the nature of perception and the influence of language on the mind; why the 'Hard Problem' of consciousness is so difficult; Bernardo's philosophy of analytic idealism; Jungian psychology & psychological archetypes; psychedelic experiences with psilocybin, 5-MeO-DMT, and how these could model the phenomenology of organic death.More content about consciousness.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off.For all the ways you can support my efforts
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Feb 23, 2022 • 1h 26min

CBD (Cannabidiol), Antiviral Drugs, SARS-CoV-2 & Cancer Biology | Marsha Rosner | 59

Send us Fan MailNick Jikomes talks to cancer biologist Dr. Marsha Rosner, who is a Professor of Cancer Research at the University of Chicago. Her lab focuses largely on understanding the biochemical signaling mechanisms that lead to the generation of tumor cells, as well as how and why cancer cells metastasize, which is when they travel from one part of the body to another.Nick and Dr. Rosner and discuss mainly a recent study she led about the antiviral effects of cannabidiol (CBD) against SARS-CoV-2, including: why a cancer lab was working with CBD to begin with; what the results of her study actually show in terms of CBD’s antiviral effects; whether other cannabinoids showed this effect. She also commented on some misconceptions that have been circulating regarding this work, and described some of the clinical trials her team is running to measure CBD’s potential as an anti-COVID drug.*Not medical advice.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off.For all the ways you can support my efforts
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Feb 15, 2022 • 1h 43min

Genomics, PCR, COVID Testing, mRNA Vaccines, Blockchain Technology, Psilocybin Mushroom & Cannabis Genomes | Kevin McKernan | 58

Send us Fan MailKevin McKernan is a renowned leader in DNA sequencing technology. He led a research team part of the original Human Genome Project and is the founder and Chief Science Officer of Medicinal Genomics, a life sciences company that distributes genetics-based platforms for quality and safety testing of legal cannabis.Nick and Kevin discussed the Cannabis genome, the genome of Psilocybe cubensis (magic mushrooms); Polymerase Chain Reaction (PCR) technology, how it works, and how it's used for COVID-19 testing; cannabinoids such as cannabidiol (CBD) and recent research indicating their potential anti-SARS-CoV-2 effects; blockchain technology for genomics data; and mRNA vaccines and SARS-CoV-2.*Not medical advice.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off.For all the ways you can support my efforts
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Feb 10, 2022 • 38min

Sci-Hub, Open Data, Freedom of Information & the Democratization of Science | Alexandra Elbakyan | 57

Send us Fan MailNick talks to Alexandra Elbakyan, the founder of Sci-hub, a shadow library website that provides free access to millions of research papers and books, without regard to copyright, by bypassing publishers' paywalls in various ways. Sci-hub is used by millions of people around the world each month, granting them free and easy access to scientific research findings. Nick spoke to Alexandra about how Sci-hub works, why she built it, and some of the legal challenges she has faced from large scientific publishing corporations. This conversation was conducted with a professional Russian-English translator, whose voice you will hear in the recording in place of Alexandra's.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off.For all the ways you can support my efforts
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Feb 3, 2022 • 1h 14min

Gut Microbiome, Diet, Inflammation, Probiotics, Skin Care, Acne, Obesity & IBS | Suzanne Devkota | 56

Send us Fan MailNick talks to Dr. Suzanne Devkota, a microbiologist whose lab studies the gut microbiome in health and disease.They discuss a variety of topics related to the gut microbiome: how it is influenced by diet; how antibiotics and probiotics affect it; different disease states and metabolic disorders, such as IBS and obesity; how gut microbes can affect the brain and behavior; the microbiome beyond the gut, including the skin; and more.*Not medical advice.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off.For all the ways you can support my efforts
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Jan 27, 2022 • 1h 36min

Diet, Eating Habits, Obesity, Food Addiction, Psychedelics, Nutrition & the Brain | Amy Reichelt | 55

Send us Fan MailNick talks to Dr. Amy Reichelt, a neuroscientist and expert on the effects of diet and nutrition on the brain. They discussed how the brain is wired to help us learn about food, how what we eat influences the function of circuits within the brain, how certain diets can actually cause damage to the brain and negatively impact learning, obesity, and other topics related to nutrition and feeding behavior in humans and animals. They also discuss the potential role that psychoactive drugs like psychedelics may have to play in treating food addiction.*Not medical advice.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off.For all the ways you can support my efforts
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Jan 20, 2022 • 1h 59min

Dinosaurs, Paleontology, Mass Extinctions, Evolution, Past & Future of Life on Earth | Paul Barrett | 54

Send us Fan MailNick talks to Dr. Paul Barrett, a paleontologist at the Natural History Museum in London, UK. Paul has spent nearly 30 years as a paleontologist studying the evolution and biology of dinosaurs and other extinct reptiles. He has authored over 200 scientific papers, and his speciality is in non-avian dinosaurs. Nick talked to Paul about all things dinosaurs, including what a dinosaur actually is; how and when dinosaurs first evolved, changed over time, and eventually went extinct; what we know about dinosaur behavior, morphology, and physiology; which dinosaurs had feathers and what colors they had; Tyrannosaurus rex and Velociraptor; the evolution of mammals; the movie Jurassic Park; and why understanding the life's past is important for understanding life in the present.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off.For all the ways you can support my efforts
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Jan 13, 2022 • 1h 30min

Phytochemistry, Biochemistry, Genomics & Breeding of Commercial Cannabis | Reggie Gaudino | 53

Send us Fan MailNick talks to Dr. Reggie Gaudino, a molecular geneticist and expert in the phytochemistry, biochemistry, genomics, and breeding of commercial Cannabis. He is the former Chief Science Officer of Steep Hill, one of the first cannabis testing labs in the US, and is currently VP of Research & Development at Frontrange Biosciences. Nick & Reggie discuss various topics related to the science of commercial Cannabis, including: it's botanical characteristics and history, the ecological reasons for why it produces psychoactive and other compounds, some of the major cannabinoids and terpenes found in Cannabis, and whether or not popular labelling systems in the legal cannabis industry (e.g. "Indica" vs. "Sativa") will tell you anything useful about the effects a product is likely to have. *Not medical advice.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off.For all the ways you can support my efforts
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Jan 6, 2022 • 1h 43min

Painkillers, Opioids, Heroin, Fentanyl, Oxycodone, NSAIDs, & Neuroscience of Pain | David Roberson | 52

Send us Fan MailNick Jikomes talks to Dr. David Roberson, a neuroscientist and co-founder of three ongoing biotech companies: Nocion Therapeutics, Blue Therapeutics, and Blackbox Bio. David is an expert in the neuroscience of pain and the conversation focuses mainly on pain: how does our brain sense and perceive pain? Why does pain sometimes become chronic, and last for a long-time? How do various classes of pain drugs work to relieve pain? They discuss NSAIDs and opioids, including oxycodone, heroin, and fentanyl, as well as some interesting novel pain drugs currently in development. A portion of the podcast has a visual component, where David shows some of the technology he has helped develop that allows for automated, high-throughput measurements of animal behavior to detect and measure pain. Towards the end, they also discuss how this tech could be used for the characterization of novel psychoactive drugs and psychedelics. *Not medical advice.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off.For all the ways you can support my efforts
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Dec 30, 2021 • 1h 33min

Systems Thinking, Organizational Structures, Building Startups, Remote Work & Control vs. Enablement | Alexandros Marinos | 51

Send us Fan MailNick talks to Alexandros Marinos, PhD, founder & CEO of the edge computing technology startup, Balena. They discuss the internal organization of complex human systems. Alex talked about how he thinks about the organizational structure of his own company and how organizational structures impact group dynamics, growth, conflicts of interest, and innovation. One interesting area Alex provided commentary and analysis on towards the end is how to make sense of the behavior of large institutional organizations, such as the Centers for Disease Control (CDC). If you’re interested in complex systems like human organizations, how the internal structures of different organizations influence what they do and how they behave, and why human organizations can sometimes behave in deranged ways, this episode will be of interest to you.*Not medical advice.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off.For all the ways you can support my efforts

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