Mind & Matter

Nick Jikomes
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10 snips
May 12, 2022 • 2h 12min

Mitochondria, Aging, Cellular Energy, Metabolism, Gray Hair Reversal & Brain-Body Communication | Martin Picard | 70

Martin Picard, an Associate Professor at Columbia University, dives into the fascinating world of mitochondria—powerhouses of our cells. He explains their crucial role in energy production, metabolism, and even emotional health. Picard discusses the surprising reversibility of gray hair linked to life stress, and how diet and exercise profoundly impact mitochondrial function. He also explores the mind-mitochondria connection, revealing how our cellular energy influences our psychological states and perceptions of time.
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May 5, 2022 • 1h 27min

Cellular Aging, Oxidative Stress, Antioxidants, Life Extension & Health Supplements | Leonard Guarente | 69

Send us Fan MailNick talks to biologist Dr. Leonard Guarente about the biology of aging, life extension, health supplements, and related topics. Dr. Guarente is a Professor of Biology at MIT, where his lab has studied the molecular and cellular mechanisms of aging for many years. He is also the co-founder and Chief Scientist of Elysium Health, which uses the science of aging to develop health supplements to combat age-related decline and technologies to help consumers understand their rate of aging. Nick and Dr. Guarente discussed many topics related to aging, including: how and why aging occurs; whether humans can achieve immortality; NAD and the core metabolic processes of cells; resveratrol, pterostilbene, and other anti-aging molecules; epigenetics and technology that can be used to calculate biological age vs. chronological age. *Not medical advice.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off.For all the ways you can support my efforts
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Apr 28, 2022 • 1h 37min

Biology of Sex Hormones, Chromosomes, Development & Evolution of Sexual Reproduction | Blanche Capel | 68

Send us Fan MailNick talks to cell & developmental biologist Dr. Blanche Capel. They discussed the nature of sexual reproduction and sexual dimorphism, including when these these things evolved, the evolutionary reasons for sexual reproduction, and the amazing diversity of mechanisms that determine the development of sexual traits across the animal kingdom; the contribution of genetic vs. environmental factors in sex determination, and how these vary across species; sex chromosomes, such as the X and Y chromosomes of humans and other mammals; sex hormones, such as testosterone and estrogen; as well as how gametes and gonads develop - these are the sex cells, such as sperm or egg, and the reproductive organs that produce them and the major sex hormones that shape sexual development; what we know, and don’t know, about the biology of puberty and sexual development after birth, as well as whether environmental factors, such as components of the diet an environmental contaminants, could be influencing sexual development.*Not medical advice.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off.For all the ways you can support my efforts
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Apr 21, 2022 • 1h 38min

Stress, PTSD, Intergenerational Trauma, Epigenetics & Psychedelic Medicine | Rachel Yehuda | 67

Send us Fan MailNick talks to neuroscientist & clinical researcher Dr. Rachel Yehuda, who is a professor of psychiatry & neuroscience at the Icahn School of Medicine at Mount Sinai, in New York. They discuss the biology and neuroscience of stress, PTSD (post-traumatic stress disorder), why people can be sensitive or resilient to stress, epigenetics, intergenerational trauma, and how MDMA and psychedelics are being explored for their ability to treat stress-related mental health conditions. *Not medical adviceSupport the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off.For all the ways you can support my efforts
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Apr 14, 2022 • 1h 33min

Psychology of Human Power, Social Status & Influence | Robert Greene | M&M 66

Send us Fan MailNick speaks to writer Robert Greene, who is the author of several books exploring different, and sometimes dark, aspects of human psychology. The discussion focuses on the subject of his first book, "The 48 Laws of Power." They discuss what power is and how it's used. Different psychological traits that people who successfully acquire power tend to have. Strategies that have been useful throughout history for acquiring more power, as well as those that lead to a loss of power. Robert talks the political scientist Niccolo Machiavelli, and how he is often misunderstood. He also gave his perspective on some influential people with power today, including Vladimir Putin, Angela Merkel, and Elon Musk. More content on social psychology & behavior.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off.For all the ways you can support my efforts
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Apr 7, 2022 • 2h 20min

Consciousness, Perception, Evolution, Spacetime & the Nature of Reality | Donald Hoffman | 65

Send us Fan MailNick talks to cognitive scientist Dr. Donald Hoffman, who is professor emeritus of cognitive sciences at UC-Irvine and the author of many scientific papers and books, including "The Case Against Reality: Why Evolution Hid the Truth from Our Eyes.” They discussed a variety of topics related to consciousness, the nature of perception, and evolution, including: how perception works; whether our conscious perceptions are accurate representations of underlying reality; the interface theory of perception, which likens our conscious perceptions to the digital icons displayed on your computer screen; language; psychedelic experiences; and the nature of reality itself, such as whether space and time are fundamental aspects of the universe, or artifacts of perception.*Not medical advice.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off.For all the ways you can support my efforts
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Mar 31, 2022 • 1h 25min

Aging, Metabolism, Calorie Restriction, NAD, Resveratrol, Rapamycin, Sirtuins, Longer Life | Joe Baur | 64

Send us Fan MailNick talks to biochemist Joe Baur, PhD, whose lab at the University of Pennsylvania studies the molecular mechanisms of aging and metabolism. They discuss: aging as a passive vs. regulated process; mechanisms of aging (DNA mutations, oxidative stress, etc.); NAD and its role in normal physiology; the biology of sirtuins; rapamycin as an immunosuppressant & modulator of aging; the effects of diet & caloric restriction on aging; the potential slowing and reversing aging, and more.*Not medical advice.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off.For all the ways you can support my efforts
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Mar 23, 2022 • 1h 29min

Microbiome-Gut-Brain Axis in Health & Disease | John Cryan | 63

Send us Fan MailNick talks to Dr. John Cryan, a Professor of Anatomy & Neuroscience at University College-Cork in Ireland whose lab studies the microbiota-gut-brain axis in health & disease.They touch on a range of topics related to how our gut microbiome affects the brain and body, including: how the microbiome affects aging and immunity; how it affects social behavior, including potential links to autism; how antibiotics and the general hyper-cleanliness of the modern world impacts the microbiome; how it affects neuropsychiatric conditions like depression; how diet influences brain inflammation; towards the end John also shared an interesting example of a food he consumes for gut health.To learn more about the microbiome, check out this content.*Not medical advice.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off.For all the ways you can support my efforts
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Mar 16, 2022 • 1h 53min

Social Cognition, Oxytocin, MDMA, Critical Periods, Metaplasticity, Autism, Psychedelics & Octopus Neurobiology | Gül Dölen | 62

Send us Fan MailNick talks to Dr. Gül Dölen, a professor of neuroscience at Johns Hopkins University. Her lab studies the circuit and synaptic mechanisms of social cognition in health and disease.Nick and Dr. Dölen discussed her research on critical periods for social reward learning in rodents, the role of oxytocin in social behavior and learning, and how MDMA ("ecstasy") promotes prosocial behavior in animals as diverse as humans, rodents, and octopuses. They also talked about how drugs like MDMA and psychedelics influence "metaplasticity," enabling environmental factors to trigger plasticity (physical changes in the brain) in a context-specific manner. Dr. Dölen also described how her research relates to developing treatments for autism, as well as her thoughts on whether the subjective effects of psychedelics and other drugs are necessary for some of their therapeutic effects.*Not medical advice.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off.For all the ways you can support my efforts
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Mar 7, 2022 • 1h 37min

Public Health, Epidemiology, Pandemics, Immunity, SARS-CoV-2 & COVID-19 Public Policy | Martin Kulldorff | 61

Send us Fan MailMartin Kulldorff, PhD is an epidemiologist & biostatistician who has been studying infectious diseases for over two decades. He was a professor at Harvard Medical School for many years, a member of the FDA’s Drug Safety & Risk Management Advisory Committee, and a former consultant for the Centers for Disease Control. In 2020, Dr. Kulldorff co-authored the Great Barrington Declaration, a document criticizing the use of society-wide lockdowns for COVID-19 and advocating for a strategy of focused protection for high-risk people. Nick and Dr. Kulldorff discussed a variety of topics related to the COVID pandemic, including the nature of how the SARS-CoV-2 virus spreads compared to other pathogens, how our public health strategy was implemented & his thoughts on how we could have handled the pandemic better, vaccine-induced immunity vs. natural immunity, vaccine efficacy, how and why various countries differed in their approach to COVID, and the health of our scientific & public health institutions in the US.*Not medical advice.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off.For all the ways you can support my efforts

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