Immune

The Immune hosts discuss how the complement system functions, and its role in early synapse loss in a mouse model of Alzheimer's disease. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Complement and microglia cause synapse loss in Alzheimer's(Science) Superresolution structured illumination microscopy Image credit Weekly Science Picks Steph- Social Media for Social Change in Scienceand Structured Illumination Microscopy video Cindy- 314 Action Vincent- Making American great again requires acting on scientific knowledge Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The Immune hosts explain how antibody molecules mature, then discuss the finding in infants of potent neutralizing antibodies against respiratory syncytial virus without somatic hypermutation. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Potent anti-RSV antibodies without somatic hypermutation (Immunity) History of vaccine enhanced RSV disease (Clin Vacc Immunol) Image credit Letters read on Immune #6 Weekly Science Picks Steph - REACTOME project (free icons) Cindy - Gender Imbalance in Stories Vincent - Trump, Tell Us About Your Flu Shot Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The ImmuoModulators provide a primer on mucosal defenses, and explain how sensitizing female mice to food allergens prevents allergic reactions in their offspring. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Food Allergy(Nat Rev Dis Prim) Maternal allergen sensitization(J Exp Med) Image credit Letters readon Immune #5 Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

Delve into the intricacies of cancer immunotherapy and the revolutionary CAR T cells. Discover how monoclonal antibodies target tumors and the innovative strategies to engineer T cells for better precision. Explore challenges like tumor evasion and the importance of co-stimulatory signals for effective treatment. From engineered kill switches to potential applications beyond cancer, the hosts discuss the future of CAR therapy, including its high costs and healthcare implications. The fascinating intersection of immunology and innovation awaits!

Explore the complexities of dengue virus vaccines and the challenges posed by antibody-dependent enhancement. The discussion dives into the design flaws of Dengvaxia, revealing why it can worsen disease in certain cases. Transitioning to Zika, the hosts delve into the promising research on bispecific monoclonal antibodies and their therapeutic implications, including innovative engineering techniques to improve efficacy. They also touch on listener queries, productivity tips, and a stunning polar bear video, making for an engaging blend of science and fun.

The hosts dive into the fascinating world of circadian clocks and their impact on lymphocyte trafficking through lymph nodes. Discover how time of day influences immune responses and the surprising link between immune genes and behavior. They also discuss the implications of vaccination timing and its effects on autoimmune conditions. Light cycles and their role in immune rhythm are highlighted, along with insights on dendritic cells. Listeners can expect a blend of science, humor, and a call to action on important scientific policies.

Cindy, Steph, and Vincent launch a new podcast, Immune, and reveal how warm temperature protects against atherosclerosis by regulating monocyte migration into the blood. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Leifer Lab at Cornell Stephanie Langel Thermoneutrality suppresses monocyte egress from bone marrow (Circ Res) Fever regulates immunity (Nat Rev Immunol) Macrophage image by Blausen Medical Weekly Science Picks Cindy - FDA approves second CAR T cell therapy Steph - Gammaherpesvirus protects against asthma Vincent - Truth Wins by Jonathan Yewdell Intro music is by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv