Immune Immune 2: Lymphocytes after dark
Nov 25, 2017
The hosts dive into the fascinating world of circadian clocks and their impact on lymphocyte trafficking through lymph nodes. Discover how time of day influences immune responses and the surprising link between immune genes and behavior. They also discuss the implications of vaccination timing and its effects on autoimmune conditions. Light cycles and their role in immune rhythm are highlighted, along with insights on dendritic cells. Listeners can expect a blend of science, humor, and a call to action on important scientific policies.
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Basic Discovery Became MS Therapy
- The sphingosine-1-phosphate receptor discovery led to MS treatments that trap lymphocytes in nodes.
- Vincent and Cindy highlight this as a clear basic-science-to-clinic success story.
Time Treatments For Better Responses
- Consider time-of-day when planning vaccinations, treatments, or experiments.
- Timing may optimize antibody responses and clinical outcomes according to circadian trafficking.
Light Entrainment And Endogenous Clocks
- Light entrains lymphocyte circadian behavior but an endogenous clock persists in darkness.
- Flipping light cycles inverts migration timing, showing external and internal control.