Health Optimization Medicine Podcast

In this episode of the Smarter Not Harder Podcast, our guest Dr. Ted Achacoso joins our host Boomer Anderson to give one-cent solutions to life's $64,000 questions that include: What is evolutionary medicine, and what is its role in the Health Optimization Medicine and Practice framework? How does Universal Darwinism play a role in health optimization medicine? How are master regulatory genes and the cell danger response related to each other? Dr. Ted is the founding pioneer of Health Optimization Medicine and Practice, a 501(c)3 nonprofit organization dedicated to helping doctors and practitioners learn how to optimize for health rather than treat disease. He is also the founder of Smarter Not Harder Inc, makers of Troscriptions. He went to med school at the age of 18, and is trained in interventional neuroradiology, toxicology and pharmacology. He is also trained in anti-aging medicine, nutritional medicine, and is an expert in hormone balancing. What we discuss: [00:00] Evolutionary medicine's role in health optimization medicine. [06:59] Medicine has gone through magical, religious, empirical, and rational phases and is now moving towards an evolutionary phase. [13:27] Health Optimization Medicine focuses on the body's mechanisms for healing, rather than just getting rid of diseases. [19:45] Universal Darwinism applies from molecules to galaxies. [25:42] Looking at cells and metabolites to understand the body's ecosystem. [31:30] Metabolic neotenization is key for optimal health. [37:28] Master regulatory genes and the cell danger response are related to each other. [43:28] The body has summer and winter metabolisms that alternate within a day, and understanding them is key. [49:34] Evolutionary medicine provides a first principles approach to health optimization. Find more from Smarter Not Harder: Website: https://troscriptions.com/blogs/podcast | https://homehope.org Instagram: @troscriptions | @homehopeorg Find out more from Dr. Ted Achacoso: https://homehope.org Get 10% Off Your Purchase of the Metabolomics Module by using PODCAST10 at https://www.homehope.org Get 10% Off your Troscriptions purchase by using POD10 at https://www.troscriptions.com Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.

In this episode of the Smarter Not Harder Podcast, our guest Brian Mackenzie joins our host Dr. Scott Sherr to give one-cent solutions to life's $64,000 questions that include: Why is CO2 so important in respiratory physiology? How does building up CO2 tolerance affect not only your parasympathetic and sympathetic nervous systems, but your aerobic and anaerobic metabolism as well? What is the importance of nasal breathing? Brian is the founder and CEO of SHIFT, a comprehensive and adaptive training program that focuses on breath control as a primary tool for improving performance. He is also the president and co-founder of the Health and Human Performance Foundation, a nonprofit organization dedicated to the research on how breath and innate tools can optimize and help health and human performance. He's an innovator in human performance on stress adaptation, and a pioneer in the development and application of custom protocols to optimize human health and performance. His work harnesses and integrates respiratory movement, strength conditioning and endurance based training approaches to elicit unprecedented positive results. His protocols have been used to accelerate and raise both mental and physical performance in world class Olympic and professional athletes, top executives and elite military operators, as well as to improve the health for people suffering from various chronic and pathological issues. What we discuss: [00:00] Understanding stress response and respiratory physiology [06:15] Positive prison population leads to positive staff population [17:59] Our attention span is decreasing due to technology and distractions. [23:29] Stress response is a human trait, hardwired in us, but we need to actively work on keeping it in check. [34:53] Hyperventilation can cause stress on the heart and disrupt the nervous system. [40:16] CO2 tolerance affects anxiety levels. [51:36] Breathing control can improve athletic performance. [57:11] Mouth breathing impacts aerobic capacity. [1:07:33] Breathing through the nose and chewing hard food can improve CO2 tolerance and prevent sleep apnea. [1:12:25] Manage stress and develop breath control before practicing breath hold techniques. [1:23:38] Manage stress by identifying stressors, avoiding reactive responses, and becoming aware of stressors in life for personal growth. [1:29:23] SHIFT is a membership site that offers programs to make everything more accessible to people. Find more from Smarter Not Harder: Website: https://troscriptions.com/blogs/podcast | https://homehope.org Instagram: @troscriptions | @homehopeorg Find out more from Brian Mackenzie: https://www.hhp-foundation.org/ Instagram: @_brianmackenzie Get 10% Off Your Purchase of the Metabolomics Module by using PODCAST10 at https://www.homehope.org Get 10% Off your Troscriptions purchase by using POD10 at https://www.troscriptions.com Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.

In this episode of the Smarter Not Harder Podcast, our guest Dr. Lucia Aronica joins our host Dr. Scott Sherr to give one-cent solutions to life's $64,000 questions that include: What is the definition of epigenetics, and what are common epigenetic modifications? What were the results from the DIETFITS study? What are the various types of epigenetic clocks, and what are the best ways to use them? Dr. Lucia Aronica is a lecturer at Stanford University and instructor of the Stanford Genomics Certificate. Her research and teaching focused on nutrigenomics: the science of how nutrition, genetics and epigenetics interact with each other to impact our health and longevity. She has 20 years of research experience from Stanford University, the University of Oxford, the University of Vienna, the University of Naples Federico II, and the University of Southern California. She's published research papers in top ranked, peer reviewed journals such as JAMA, Cell, and Genes & Development. What we discuss: [00:00] Health optimization medicine focuses on optimizing health through epigenetic biomarkers and metabolomics. [05:36] Epigenetic modifications involve DNA methylation and histone modifications that regulate gene expression. [14:30] Epigenetics affects our health through lifestyle choices and can be viewed as a secret agent of optimization medicine. [21:13] Lifestyle can override the effect of common genetic variants. [27:39] The DIETFITS study analyzed biomarkers to determine which categories of people would benefit from low-carb or low-fat diets [41:40] Reduce carb intake and increase whole food intake for better metabolic and brain health. [48:19] Omega-3s are conditionally essential nutrients which are difficult to synthesize from plant-based sources, making it better to get them from animal-based sources. [54:29] Epigenetic clocks can estimate biological age and capture functional changes in the body but there's a catch [1:00:57] Be cautious about using epigenetic clocks for clinical utility [1:07:26] Sign up for Dr. Lucia Aronica's webinar on epigenetics and longevity Find more from Smarter Not Harder: Website: https://troscriptions.com/blogs/podcast | https://homehope.org Instagram: @troscriptions | @homehopeorg Find out more from Dr. Lucia Aronica: https://draronica.com/ LinkedIn: https://www.linkedin.com/in/luciaaronica/ Instagram: @drluciaaronica Dr. Aronica's free webinars and new certificate course in epigenetics: https://draronica.podia.com Get 10% Off Your Purchase of the Metabolomics Module by using PODCAST10 at https://www.homehope.org Get 10% Off your Troscriptions purchase by using POD10 at https://www.troscriptions.com Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.

In this episode of the Smarter Not Harder Podcast, our guest Dr. Joscha Bach joins our host Dr. Ted Achacoso to give one-cent solutions to life's $64,000 questions that include: Will physicians and other healthcare providers be replaced by AI technologies? Can AI help solve the most frightening aspects of US healthcare, or are we beyond solutions? What is the future of conscious machines? Dr. Joscha Bach is a renowned AI researcher and cognitive scientist, known for his work in understanding the complex architecture of the human mind. Dr. Bach holds a Ph.D. in Cognitive Science from the University of Osnabrück in Germany, and has worked as a research scientist at the MIT Media Lab, as an affiliate at the Harvard Program for Evolutionary Dynamics, and as Principal AI Engineer at Intel Labs Cognitive Computing group. He has published extensively on cognitive architectures, mental representation, emotion, social modeling, and multi-agent systems. This may be the very first recorded conversation with Dr. Bach that is centered on the role of AI in medicine and health care. What we discuss: [00:00] Empathy is important, but it's also important to develop distance and reflection about yourself. [06:38] AI-generated medical suggestions can be useful but should not be the sole source of advice. [18:14] Alternative regulatory systems can compete with existing ones to introduce pressure for change. [23:51] Regulation can stifle innovation and harm new industries. [35:15] Automated decision tools can create a degree of fairness that you might otherwise not have. [40:52] Understanding death as a part of life and dying with dignity. [52:19] Building an empathetic AI is possible, but it requires a deep understanding of moral and ethical contexts. [57:33] AI's role in advancing diagnostics and therapeutics. [1:09:10] Simulation can aid in identifying factors but real-world context is important. [1:14:48] The only difference between a drug and a poison is the dose. [1:25:39] Exploring the relationship between biological life and consciousness. [1:31:17] Developing a self requires coupling to the world and discovering oneself in it. [1:42:10] Health optimization medicine regards the body as an ecosystem of cooperating and competing cells in the network. [1:47:49] AI can be helpful in healthcare, but professionals need to understand the formal tools to make progress. [1:58:45] Adaptive AI for industrial robots [2:04:30] Building meaningful relationships is the most important thing in life. Find more from Smarter Not Harder: Website: https://troscriptions.com/blogs/podcast | https://homehope.org Instagram: @troscriptions | @homehopeorg Find out more from Joscha Bach: Website: http://bach.ai/ Twitter: @plinz Get 10% Off Your Purchase of the Metabolomics Module by using PODCAST10 at https://www.homehope.org Get 10% Off your Troscriptions purchase by using POD10 at https://www.troscriptions.com Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.

In this episode of the Smarter Not Harder Podcast, our guest Dr. Michael Levin joins our host Dr. Ted Achacoso to give one-cent solutions to life's $64,000 questions that include: Can we unlock the secrets of limb regeneration to revolutionize the future of medicine? How can we harness the power of cellular communication to control cancer growth? What are the ethical and practical implications of creating programmable living machines known as xenobots? Dr. Michael Levin is an acclaimed American developmental and synthetic biologist at Tufts University. As a Vannevar Bush distinguished professor, Dr. Levin has made a remarkable impact in the field of biology, challenging the limits of our understanding and pushing the boundaries of scientific discovery. What we discuss: [00:00] Dr. Michael Levin's groundbreaking research is shaping the future of biology, medicine, and ethics. [06:25] Bioelectric circuits can be manipulated to grow functioning organs [17:44] Anatomical homeostasis may be the reason for regeneration of limbs in frogs and salamanders [33:02] Xenobots challenge our understanding of natural selection [37:54] Mathematics and geometry have an independent life separate from physical facts of the universe. [53:03] Understanding diverse spaces where intelligence can function. [1:03:23] Planarian bioelectric circuits can be rewritten to alter memory and guide regeneration. [1:18:56] Multicellularity enables cells to work in a different problem space and expand their cognitive light cone. [1:24:06] Recognizing and relating to diverse intelligences through a framework, tools, and ethical considerations. [1:34:31] Understanding and studying agency in unfamiliar embodiments is crucial for the future of living with cognitive systems. [1:39:28] Consider ethics in scientific advancements [1:50:11] Medical informatics is a process of discovering beyond the wall of knowledge. Find more from Smarter Not Harder: Website: https://troscriptions.com/blogs/podcast | https://homehope.org Instagram: @troscriptions | @homehopeorg Find out more from Michael Levin: Website: https://wyss.harvard.edu/team/associate-faculty/michael-levin-ph-d/ Twitter: @drmichaellevin Get 10% Off Your Purchase of the Metabolomics Module by using PODCAST10 at https://www.homehope.org Get 10% Off your Troscriptions purchase by using POD10 at https://www.troscriptions.com Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.

In this episode of the Smarter Not Harder Podcast, our guest Rachel Gerrol joins our host Dr. Scott Sherr to give one-cent solutions to life's $64,000 questions that include: What is Nexus, and how has it evolved over the many years since it started? How do the members of Nexus work together to do amazing things all over the world? What are three ways to make your life smarter, not harder? Rachel Gerrol is widely recognized for her work on millennial philanthropy and community building and has been featured in The New York Times, Financial Times, The Atlantic, Forbes, Vanity Fair, and more. She helped organize the "White House Conference on Next Gen Philanthropy & Impact Investing" for the Obama administration and worked closely with Vice President Biden to develop the "It's On Us" campaign to address sexual assault on campus, which she continues to be an advisor for today. Rachel has received multiple awards and was named in the "Top 99 Foreign Policy Leaders Under 33" by the Diplomatic Courier. What we discuss: 00:02:34: Rachel's background in philanthropy 00:05:15: How Rachel became a Philanthropist 00:12:19: What is Nexus? 00:16:57: The challenges of bringing many different people together 00:20:31: The social impact of Nexus 00:27:12: How Nexus supports members all over the world 00:34:41: How to maintain networks and connections 00:39:11: Where is Nexus going in the next 3 to 5 years? 00:43:10: Three ways to help make your life smarter, not harder Find more from Smarter Not Harder: Website: https://troscriptions.com/blogs/podcast | https://homehope.org Instagram: @troscriptions | @homehopeorg Find out more from Rachel Gerrol: Website: https://nexusglobal.org/ LinkedIn: https://www.linkedin.com/in/rachelgerrol/ Instagram: @rachelgerrol Twitter: @rachelgerrol Get 10% Off Your Purchase of the Metabolomics Module by using PODCAST10 at https://www.homehope.org Get 10% Off your Troscriptions purchase by using POD10 at https://www.troscriptions.com Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.

In this episode of the Smarter Not Harder Podcast, our guest Dr. Thierry Hertogue joins our host Dr. Ted Achacoso to give 1 cent solutions to the following $64,000 questions: Are hormones perhaps the best psychedelics? How can we use the hormones produced in the seven neuroendocrine axis to anti-age? Can doctors and health care practitioners be taught to include spirituality in practice? Dr. Thierry Hertoghe pioneered anti-aging medicine using hormones to balance the system into health. He discusses hormone balancing in the podcast. [00:00] Dr. Thierry Hertoghe is an anti-aging expert who uses hormones to balance the body for health [00:40] Why Testosterone and DHEA are essential for overall health [08:31] Growth hormone can improve health, increase freshness, and reduce anxiety in people above 35-40 years [16:03] Peptides are not as effective as growth hormone for stimulating growth due to their effects on only one receptor. [23:36] Thyroid hormone balancing improves bowel movements and intelligence [30:53] Control blood sugar levels with insulin, alpha lipoic acid, and chromium [38:31] Cortisol deficiency leads to severe health problems [53:01] Hormone treatment has good effects if given from pre-menopause to women up to age 60-65 [1:00:01] Balancing estrogen and progesterone is crucial to avoid negative symptoms and improving quality of life. [1:07:22] Spirituality and hormone balancing are essential for overall health. [1:22:13] Incorporating spirituality into medicine will lead to better healing. Find more from Smarter Not Harder: Website: https://troscriptions.com/blogs/podcast | https://homehope.org Instagram: @troscriptions | @homehopeorg Find out more from Dr. Thierry Hertoghe: Website: https://www.hertoghe.eu/en/ Facebook: https://www.facebook.com/DrHertoghe/ Instagram: @dr.hertoghe LinkedIn: https://www.linkedin.com/in/thierry-hertoghe-md-839386b7/ Youtube: https://www.youtube.com/user/HertogheMedschool Get 10% Off Your Purchase of Metabolomics Module by using PODCAST10 at https://www.homehope.org Get 10% Off your Troscriptions purchase by using POD10 at https://www.troscriptions.com Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.

In this episode of the Smarter Not Harder Podcast, our guest Dr. Andrew Gallimore joins our host Dr. Ted Achachoso to give 1 cent solutions to the following $64,000 questions: Does dimethyltryptamine make the brain construct a different reality or does it make the brain perceive a different reality based on the information that it was receiving? How do molecules such as LSD, DMT, psilocybin, and mescaline switch one's reality from one channel to another Why is the fly agaric psychedelic? Dr. Andrew Gallimore is a British neurobiologist, chemist, pharmacologist and writer based in Tokyo, Japan. He has been interested in the relationship between psychedelic drugs, the brain, consciousness, and the structure of reality. He has written a couple of books that he illustrated and self-published. His works are Alien Information Theory: Psychedelic Drug Technologies, and the Cosmic Game (2019), and Reality Switch Technologies: Psychedelics as Tools for the Discovery and Exploration of New Worlds (2022). What we discuss: [00:00] Dr. Andrew Gallimore discusses his self-published book on psychedelic drug technologies and the structure of reality [09:12] DMT and Conway's Game of Life illustrate the emergence of complexity from simple rules [25:29] DMT experience reveals highly intelligent, hyper-dimensional space beyond our reality [34:06] DMT allows the brain to construct an alternate reality without affecting critical parts. [49:36] Salvanorin inhibits the claustrum, which releases the cortex and creates novel emergent patterns of activity. [57:19] Salvia tears apart the fabric of reality while classic psychedelics allow the brain to reach new states [1:12:43] Different drugs affect perception and reality in different ways. [1:20:42] Inhibitory interneurons control excitation inhibition balance [1:36:11] Positive allosteric modulators can enhance receptor activity without the presence of an endogenous agonist. [00:15] Muscimol and its Psychedelic Properties Find more from Smarter Not Harder: Website: https://troscriptions.com/blogs/podcast | https://homehope.org Instagram: @troscriptions | @homehopeorg Find out more about Dr. Andrew Gallimore: Website: http://alieninsect.net/ Twitter: @alieninsect Instagram: @alieninsect YouTube: youtube.com/c/alieninsect Books: Alien Information Theory: Psychedelic Drug Technologies and the Cosmic Game Reality Switch Technologies: Psychedelics as Tools for the Discovery and Exploration of New Worlds Get 10% Off Your Purchase of Metabolomics Module by using PODCAST10 at https://www.homehope.org Get 10% Off your Troscriptions purchase by using POD10 at https://www.troscriptions.com Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.

In this episode of the Smarter Not Harder Podcast, our guest Dr. Nasha Winters joins our host Dr. Scott Sherr to give one-cent solutions to life's $64,000 questions within the cancer realm. Dr. Nasha dives into integrative cancer care and opening a metabolic oncology hospital. Dr. Nasha Winters is a global healthcare authority and a best-selling author in integrative cancer care and research. She has educated hundreds of professionals in the clinical use of mistletoe, and created robust educational programs for both healthcare institutions and the public on incorporating vetted integrative therapies and cancer care to enhance outcomes. Dr. Winters is currently focused on opening a comprehensive metabolic oncology hospital and research institute in the United States. What we discussed: [00:00] High insulin levels desensitize cancer cells to radiation [07:20] 10 major drivers to evaluate for each individual's mitochondrial bucket [19:33] A data-driven, individualized approach is key to successful patient outcomes. [25:52] Comprehensive patient history is crucial to evaluate hormone health. [38:23] Gut health plays a significant role in the immune system and cancer therapies [44:46] Individualized treatment is the future of Integrative Oncology. [57:02] Oxidative therapies [1:03:28] Cancer is a manageable disease process, and standard oncology needs to adapt. [1:15:18] Movement towards caring for emotional and mental well-being Find more from Smarter Not Harder: Website: https://troscriptions.com/blogs/podcast | https://homehope.org Instagram: @troscriptions | @homehopeorg Find out more about Dr. Nasha Winters: Website: https://www.drnasha.com/ Books: https://www.drnasha.com/matcbook/ Facebook: https://www.facebook.com/drnashainc/ LinkedIn: https://www.linkedin.com/in/nasha-winters-796374b6/ Twitter: https://twitter.com/drnashawinters Instagram: @drnashawinters YouTube: https://www.youtube.com/channel/UCn932xLBUY91v9OHE0YuR6A Get 10% Off Your Purchase of Metabolomics Module by using PODCAST10 at https://www.homehope.org Get 10% Off your Troscriptions purchase by using POD10 at https://www.troscriptions.com Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.

In this episode of the Smarter Not Harder podcast, host Dr. Ted Achacoso is joined by Dr. Anna Lembke who educates us on the opioid epidemic and answered the question: how can a person get addicted to pain? Doctor Anna Lembke is a professor and the medical director of Addiction Medicine at Stanford University School of Medicine, and a New York Times Best Selling author. She received her undergraduate degree in humanities from Yale University and her medical degree from Stanford University. Dr. Lembke is a diplomat for both the American Board of Psychiatry and Neurology, and the American Board of Addiction Medicine. She is also a specialist in the opioid epidemic of the United States. She appeared in the 2020 subcommittee The Social Dilemma. Her works include "How Doctors Were Duped, Patients Got Hooked, and Why It's So Hard to Stop," and the New York Times bestseller "Dopamine Nation: Finding Balance in the Age of Indulgence" which was released in August 2021. What we discuss: 00:00:40 - About Dr. Anna Lembke 00:01:45 - Uncovering co-occurring addictions alongside subsctance abbuse 00:03:46 - Uncovering substance addictions with behavioral-addicted patients 00:04:54 - Is it true that people have addictive personalities? 00:08:02 - Decreasing the amount of the addictive substance over time vs. total abstinence immediately 00:13:16 - Statistics on substance addiction 00:18:14 - How dopamine plays into addiction 00:22:23 - The journey to abuse 00:30:08 - How does one get addicted to pain? 00:39:28 - What happens to dopamine once abstinent 00:42:55 - How does opiate induced hyperalgesia happen? 00:46:25 - How does mindfulness help with addiction? 00:52:02 - Is romantic love an addiction? 00:53:48 - Should hard and sudden heartbreak be treated with drugs from sudden dopamine drops? 00:57:42 - Can psychedelics lead to addiction? Can it help in mitigating addiction? 01:00:29 - Smarter not harder advice to parents on how their children can navigate the dopamine nation Find more from Smarter Not Harder: Website: https://troscriptions.com/blogs/podcast | https://homehope.org Instagram: @troscriptions | @homehopeorg Find out more about Dr. Anna Lembke: Website: https://www.annalembke.com/ Dopamine Nation: https://www.annalembke.com/dopamine-nation Publications: https://www.annalembke.com/selected-publications Get 10% Off Your Purchase of Metabolomics Module by using PODCAST10 at https://www.homehope.org Get 10% Off your Troscriptions purchase by using POD10 at https://www.troscriptions.com Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.