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Edmund McMillen

Indie game designer and artist best known for Super Meat Boy and The Binding of Isaac, serving here as the episode's featured guest to discuss his new game Mewgenics and its long development.

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7 snips
Mar 3, 2026 • 48min

Why the Mewgenics developers never even considered a publisher

Tyler Glaiel, a designer/programmer who co-developed Mewgenics, and Edmund McMillen, creator of The Binding of Isaac and Super Meat Boy, talk about Mewgenics' surprise breakout success. They discuss the game's long, iterative development, choosing tactical strategy over easier routes, why they avoid publishers to preserve creative control, hands-on marketing, and recruiting talented fans.
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Feb 9, 2026 • 48min

Edmund McMillen Is Still Nervous About Releasing a Video Game

Edmund McMillen, indie game designer and artist behind Super Meat Boy and The Binding of Isaac, talks about releasing his tactics-focused game Mewgenics. He shares launch nerves despite past hits. He explores how parenting, neurodiversity discoveries, and collecting hobbies shaped the game's themes and mechanics. He also discusses designing for different playstyles and hoping for slow-burn success.
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Feb 6, 2026 • 2h 20min

Mewgenics Interview, Don't Stop, Girlypop!, Perfect Tides: Station to Station

Edmund McMillen, game designer and artist behind Super Meat Boy and The Binding of Isaac, and Tyler Glaiel, indie developer and collaborator on Mewgenics. They talk about Mewgenics' polish and animation variety. They debate Adobe Animate changes, discuss launch readiness, localization quirks, controller and virtual-mouse choices, and lively community audio contests.
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Feb 16, 2026 • 1h 10min

Edmund McMillen Wants You to Ask the Uncomfortable Questions

Edmund McMillen, indie designer behind The Binding of Isaac and Super Meat Boy contributor, talks about provocative beginnings and how shock turned into purposeful, emotional game design. He explores Mewgenics’ long, controversial development, integrating real disorders into mechanics. He explains turning difficult subjects into playable strengths and why this project feels like his career culmination.
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Feb 14, 2026 • 2h 34min

Mewgenics creator Edmund McMillen stops by to chat life, review scores & more | FPS #88

Edmund McMillen, indie designer of Binding of Isaac and Super Meat Boy, talks Mewgenics' long development, cat-breeding themes, and massive item/ability scope. Oliver Merlöv, CEO of Tarsier Studios, explains Re-Animal’s design, co-op choices, and companion AI challenges. Multiple short conversations cover launch plans, studio size, and post-release creative roadmaps.

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