The Gut Health Masterclass: Making Science Digestible With Dr. Will Bulsiewicz

Feb 17, 2026

01:14:42

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On today’s episode of the CLS Experience, host Craig Siegel sits down with board-certified internal medicine physician and gastroenterologist Dr. Will B to explore the science and soul of gut health. They break down the gut microbiome as a community of roughly 38 trillion microbes that influence digestion, immunity, metabolism, hormones, mood, and even brain health. Dr. B emphasizes authentic connection - to self, others, and spiritual wellbeing - as foundational to true health, and shares his own journey of burnout, weight gain, depression, and ultimate transformation through dietary change. The conversation challenges medication-first healthcare and instead champions a root-cause, lifestyle medicine approach built on nutrition, sleep, stress management, exercise, and consistency. They dive deep into fiber as the missing nutrient in 95% of American diets, the power of short-chain fatty acids, the gut–brain connection, IBS reversal, coffee as a gut-health beverage, alcohol and gut permeability, and the importance of small daily habits. This could extend your life - let's go deep.

6:42 Gut Microbiome 101: Why It’s the Body’s Command Center

14:53 Fiber Deficiency & Microbiome Diversity

25:09 Short-Chain Fatty Acids, GLP-1 & Brain Health

33:53 Dr. B’s Personal Health Transformation

48:54 Coffee, Consistency & Daily Habits

52:30 Alcohol, Leaky Gut & Microbial Endotoxins

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