#340: Dave Asprey on Biohacking, Longevity, and Living to 180 (Kale Is Out, Stem Cells Are In) | The Longevity Revolution Explained

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Jun 3, 2025

In this engaging conversation, Dave Asprey, founder of Bulletproof and a leading figure in biohacking, shares his insights on longevity and health optimization. He discusses the innovative applications of stem cell therapy and the transition from traditional health trends like kale. The importance of joy, personalization in wellness, and making health metrics more accessible through AXO Health are also highlighted. Asprey emphasizes the interconnectedness of advanced therapies and a proactive approach to health, exploring the future of biohacking and its societal implications.

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INSIGHT

Metabolism Links Happiness and Longevity

Happiness and longevity are interconnected through metabolic health.
Fixing metabolism often naturally increases desire for longer life.

ADVICE

Thyroid Health Optimization Tips

When thyroid function is borderline, consider lifestyle changes before medication.
Try iodine, tyrosine, and boron supplements to optimize energy and metabolism.

ADVICE

Vitamin and Mineral Longevity Foundation

Start foundational longevity with fat-soluble vitamins D, A, K, E alongside minerals.
Adequate mineral intake supports stronger bones, metabolic efficiency, and longevity.

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I had the chance to sit down with one of the original pioneers of the biohacking movement: Dave Asprey. You probably know Dave as the founder of Bulletproof, the mastermind behind putting butter in coffee, and the creator of Upgrade Labs and the Biohacking Conference. He's also a four-time New York Times bestselling author.

What we discuss:

Biohacking's relationship with longevity and functional medicine ... 00:10:47

The importance of energy, joy, and personalization in longevity ... 00:14:28

Democratizing lab tests and health optimization with AXO Health ... 00:24:00

Most common health imbalances: thyroid, hormones, minerals ... 00:33:25

Danger Coffee and foundational supplement protocols ... 00:39:43

Pitfalls of oversimplification in health and biohacking ... 00:45:52

Making advanced therapies and tech more accessible ... 00:53:23

Ethical and societal considerations in radical longevity ... 01:07:00

Where to find Dave Asprey and closing remarks ... 01:11:58

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