Core IM | Internal Medicine Podcast

#53 Heparin-Induced Thrombocytopenia: 5 Pearls Segment

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Nov 13, 2019
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INSIGHT

HIT Onset

  • Rapid-onset HIT occurs immediately after heparin exposure in previously exposed patients.
  • Typical-onset HIT develops after 5-10 days, allowing time for antibody formation.
INSIGHT

HIT Risk Factors

  • Surgical patients have a higher HIT risk than medical patients.
  • Unfractionated heparin poses a greater risk than low-molecular-weight heparin.
ADVICE

4T Score

  • Suspect HIT in thrombocytopenia with clotting, not just bleeding risk.
  • Use the 4T score (thrombocytopenia, timing, thrombosis, other causes) to assess HIT probability.
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