#53 Heparin-Induced Thrombocytopenia: 5 Pearls Segment
Core IM | Internal Medicine Podcast
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Hit Antibodies - What Are They?
Hit can be defined as an antibody-mediated activation of platelets with heparin exposure that leads to thrombocytopenia and in some cases venous or arterial thrombosis. Antiretitirate, that is a 6% daily risk,. I had no idea that was the case before going down this rabbit hole. We call them hit antibodies. They do what we all learn about in medical school and then promptly forgot after step 1. When a platelet becomes activated, it changes shape. It sort of goes from being kind of like a nice round shape to having almost like pseudopodia. And it releases the contents of certain granules into
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