Live Well Be Well with Sarah Ann Macklin | Health, Lifestyle, Nutrition

Can gut bacteria influence brain disease? The microbiome, Parkinson’s and dementia | William Li

Jan 30, 2026

William Li, physician-researcher exploring biology and health. He discusses whether specific gut and mouth bacteria can affect brain health. Short segments cover Lactobacillus plantarum PS128 and Parkinson’s, links between gum disease and dementia, and Lactobacillus reuteri’s ties to oxytocin and social brain function.

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INSIGHT

Brain Regeneration Is Possible

Long-held beliefs about inevitable brain decline and lack of regeneration are being reconsidered.
New research shows the brain can regenerate and regain functions once thought permanently lost.

INSIGHT

Single Bacteria Can Affect Parkinson's

Specific gut bacteria can influence brain health and disease progression.
Early studies show Lactobacillus plantarum (PS128) may slow Parkinson's progression in humans.

ANECDOTE

Personal Drive To Find Brain-Helpful Bacteria

William Li recounts searching for bacteria that could help the brain after a friend with ALS declined.
That search led him to study Lactobacillus plantarum and its potential benefits.

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Can specific gut and mouth bacteria influence brain health and conditions like Parkinson's or Alzheimer's? We look at early clinical work on Lactobacillus plantarum PS128 and its potential to slow Parkinson's progression, links between gum disease and dementia, and how Lactobacillus reuteri may stimulate oxytocin. This clip explores the gut-brain and oral-brain connections, the idea of a brain microbiome, and emerging views on brain regeneration and healthy aging.

Watch the FULL podcast here: https://youtu.be/yZDzsfNjG_M

William Li in conversation with Sarah Ann

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