Siim Land Podcast #449 Matt Kaeberlein Unleashed: Rapamycin, Peptides, Protein, Supplements Q&A
Apr 17, 2025
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Promising Longevity Compounds
- SGLT2 inhibitors and estrogens show promising data for lifespan extension and healthspan improvement.
- Metformin benefits mostly diabetics but may blunt exercise benefits in healthy people.
Limits of Biological Age Tests
- Consumer biological age tests show high variability and lack regulatory validation.
- Current molecular clocks correlate with mortality risk but don't definitively measure biological age.
Use GLP-1 Agonists Wisely
- GLP-1 agonists may extend lifespan beyond calorie restriction effects but require diet and resistance training to maintain muscle.
- Be cautious with peptides; many lack longevity evidence and have unknown risks.