The Jesse Chappus Show 666: Hormone Expert: The Fastest Way to Insulin Resistance & the Big Lie About Calories! | Dr. Robert Lustig
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Aug 19, 2025 
Dr. Robert Lustig, a neuroendocrinologist and bestselling author, dives deep into the myths surrounding insulin resistance and calorie counting. He uncovers how dysfunctional mitochondria contribute to metabolic issues and critiques the impact of ultra-processed foods on fat storage. Lustig reveals the interplay between hormones like cortisol and insulin in fat accumulation, discusses the harmful effects of fructose from sugary drinks, and emphasizes the critical role of fiber in improving metabolic health. Intermittent fasting also gets a nod for its potential benefits on liver health.
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Three Kinases Decide Growth Or Burning
- PI3K, AMPK, and mTOR coordinate growth vs. burning; dyssynchrony of these kinases causes chronic disease.
- Mitochondrial ROS and metabolic status set their phosphorylation and thus cell fate.
Glucose Hurts Small Vessels, Insulin Large Ones
- High glucose causes microvascular (small-vessel) damage, while high insulin causes macrovascular growth-related disease.
- Diabetes harms both small and large vessels via different mechanisms.
Get These Core Labs For Insulin Risk
- Ask your clinician to check fasting insulin, fasting glucose, A1C, lipid panel with APOB and triglycerides, ALT, and uric acid.
- Use these inexpensive tests to assess insulin resistance and fatty liver risk.