ICU Ed and Todd-Cast New/New: PE and CPR Guidelines
Mar 24, 2026
They walk through brand new pulmonary embolism risk categories and how they change triage and treatment choices. They highlight timing and options for anticoagulation, advanced clot therapies, and follow-up for chronic thromboembolic disease. They also cover 2025 CPR and resuscitation guideline changes including BLS/ACLS updates, mechanical and extracorporeal CPR considerations, pregnancy resuscitation, and training innovations.
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Do Start Anticoagulation Immediately For PE
- Start anticoagulation promptly for most acute PE patients and do not delay while considering advanced therapies.
- Even if planning catheter or surgical thrombectomy, begin anticoagulation unless clear contraindication exists.
PERT Teams Strongly Recommended Despite Limited RCT Evidence
- The guideline gives a strong recommendation (Class I, level B non-randomized) to implement PE Response Teams (PERT) at hospitals with admitted PE patients (C2–E2).
- Evidence shows reduced time-to-anticoagulation and fewer IVC filters but mixed data on length of stay and mortality.
PERT Team Resource Burden And Practical Limits
- Eddie and Todd note PERT setup is resource intensive and may be impractical for smaller hospitals.
- Todd compares PERT to calling nephrology for a creatinine of 1.4 — sometimes unnecessary but intended to catch patients who need advanced therapy.