3550: Signos and the Case for Seeing Your Metabolism in Real Time

Jan 11, 2026

Sharam Fouladgar-Mercer, CEO and co-founder of Signos, shares insights on revolutionizing weight management through continuous glucose monitoring and AI. He explains how real-time metabolic data can transform our understanding of food choices and exercise routines. Sharam emphasizes the importance of personalization over generic diets, revealing simple strategies like changing food order and timing for better glucose stability. His own journey of losing 25 pounds while increasing calorie intake serves as an inspiring testament to Signos' innovative approach.

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INSIGHT

See Your Metabolism In Real Time

Continuous glucose monitoring (CGM) lets people see their metabolism in real time and reveals how bodies differ.
Signos uses that visibility to personalize weight-management actions rather than applying one-size-fits-all rules.

INSIGHT

Maintenance Matters As Much As Loss

Weight management requires both losing weight and maintaining it long-term.
Personalized metabolic data enables tailored plans for loss and maintenance rather than generic diets.

INSIGHT

FDA Clearance Expands Access

FDA clearance lets Signos offer CGMs over-the-counter and widen access beyond prescriptions.
Over-the-counter availability can reduce cost, increase adoption, and enable FSA/HSA eligibility.

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What if the biggest breakthrough in weight management is not a new diet, but finally seeing how your body responds in real time?

That question sat at the center of my conversation with Sharam Fouladgar-Mercer, CEO and co-founder of Signos, a continuous glucose monitoring (CGM) and AI-powered health platform built to help people manage weight by understanding their metabolism. January is when motivation is high and the wellness noise is loud, but it is also when a lot of people realize how hard it is to stick with generic advice that does not fit real life. This episode is about why personalization matters, how metabolic signals can change the way you think about food and exercise, and what happens when health technology shifts from reporting the past to guiding the next decision.

Sharam explained how Signos pairs a CGM with an AI-driven experience that turns glucose data into practical actions. The point is not to force people into rigid rules or extreme restrictions. Instead, it is about learning how your body reacts to everyday choices, then using that feedback to reduce spikes, improve consistency, and build habits you can actually live with. We talked about simple interventions, like changing the order of foods in a meal, timing movement more intelligently, and spotting patterns that would otherwise stay invisible.

Two personal stories brought the conversation to life. Sharam shared how he lost 25 pounds while increasing his calorie intake, which challenges a lot of assumptions people carry into weight loss. He also shared a story from his family life, where his wife's deep sleep increased from roughly 20 minutes a night to around 60 minutes after focusing on glucose stability, even while total sleep time remained limited during the intense period of raising young kids. It is the kind of detail that hits home for anyone who has ever tried to make healthier choices while exhausted and stretched thin.

We also explored why FDA clearance matters for Signos and what that could mean for mainstream access. Over-the-counter availability reduces friction, can lower cost, and opens the door to broader adoption, including potential FSA and HSA eligibility. Looking ahead, Sharam shared a vision that goes beyond weight management, connecting metabolic health to the long arc of prevention and chronic conditions where insulin resistance plays a role.

If you have ever felt like you are doing all the "right" things and still not seeing results, this episode will make you rethink what "right" even means. And if you could finally see your metabolism in real time, would it change how you approach food, sleep, exercise, and the habits you want to keep this year?

Useful Links

Connect with Sharam Fouladgar-Mercer
Learn more about Signos
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Thanks to our sponsors, Alcor, for supporting the show.