Siim Land Podcast

#330 The 7 Tenets of Aging - Dr Sandra Kaufmann

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Oct 6, 2022
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INSIGHT

Balance AMPK And mTOR By Timing

  • AMPK and mTOR act oppositely: AMPK induces a hibernation-like longevity state while mTOR supports growth and turnover.
  • Optimal aging requires timing these pathways to match goals (e.g., muscle maintenance vs longevity).
ADVICE

Be Cautious With Rapamycin Use

  • Don't start rapamycin lightly; its powerful mTOR inhibition harms fast-turnover tissues and memory.
  • Prefer waiting for selective 'rapalogs' or targeted dosing schedules validated in humans.
ADVICE

Support Protein Quality Control

  • Boost proteostasis with heat/cold shock and chaperone upregulators to prevent misfolded protein accumulation.
  • Encourage autophagy intermittently to recycle damaged components but mind long-lived cell waste like lipofuscin.
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