LONGEVITY with Nathalie Niddam #406: Peptide OVERLOAD: When Biohacking Backfires (How NOT to Crash Your Mitochondria) With Anthony Castore
Jan 23, 2026
In this engaging conversation, Anthony Castore, a strength coach turned cellular medicine expert and founder of Alchemiq Labs, shares his journey through fitness and science. He dives into the crucial balance between AMPK and mTOR for performance optimization, explains the significance of lifestyle and nutrition before peptides, and offers insights into mitochondrial health. Anthony also emphasizes caution with peptide stacking, recounting a personal experience of overdoing interventions. His focus on individualized recovery and optimizing daily function makes for an enlightening discussion!
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Balance AMPK And mTOR For Adaptation
- AMPK acts like a fuel gauge and mTOR like a gas pedal; balancing them times cleanup and growth signals for optimal adaptation.
- Training, circadian alignment, nutrition, and peptides must be timed to push the right lever at the right time.
Cycle Training Types Intentionally
- Toggle between metabolic, tension-based hypertrophy, and neural training based on recovery signals and goals.
- Pivot training type when sleep, digestion, soreness, or set-to-set recovery indicate poor adaptation.
Build The Foundation Before Peptides
- Build a wide foundation: prioritize lifestyle, then training, then nutrition, and add peptides only after those basics are solid.
- Avoid using peptides to patch poor sleep, diet, or training; start with one peptide and test before adding more.