Dr. Jockers Functional Nutrition

GABA, Methylene Blue, Mitochondria and The Parasympathetic Edge with Dr Scott Sherr

Mar 24, 2026
Dr. Scott Sherr, a board-certified internist specializing in mitochondrial support and hyperbaric and integrative therapies. He breaks down why people get stuck in fight-or-flight and why slowing down improves performance. Topics include GABA as the brain’s brake, gut inflammation’s role in nervous system balance, mitochondrial drivers of fatigue, methylene blue as a short-term energy bridge, and hyperbaric oxygen basics.
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INSIGHT

Supplemental GABA Works Only With Leaky Barrier

  • Oral GABA supplements only work when the blood-brain barrier is leaky; paradoxically repairing gut/blood-brain barrier can stop supplemental GABA from working.
  • Sherr observed patients who lost GABA supplement response after gut healing.
ADVICE

Don't Calm Without Cellular Support

  • When calming interventions are used, simultaneously bolster mitochondrial capacity to avoid crashes.
  • Sherr warns patients often crash after anxiolytics if mitochondria lack energy or detox capacity.
ADVICE

Use Low Dose Methylene Blue As An Energy Bridge

  • Use low-dose methylene blue as a short-term bridge to restore energy and detox capacity while building long-term mitochondrial support.
  • Sherr recommends clean formulations and typical doses ~4–25 mg, combining with red light for synergy.
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