Mitochondrial Dysfunction: Root Causes

Sherr reviews drivers of mitochondrial stress: insulin resistance, infections, toxins, meds, and nutrient depletion.

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In this episode, Dr. Jockers sits down with Dr. Scott Sherr to break down why so many people are stuck in fight or flight and what it's really doing to your brain and body. You'll learn how GABA acts as the "brake system" for your nervous system and why low levels are linked to anxiety, poor sleep, and burnout. They also unpack why fixing stress is not just mental, but deeply biological.

You'll get a clearer picture of what's actually going on inside your cells when you feel exhausted, wired, or mentally foggy. Dr. Sherr explains how your mitochondria play a central role in all of it and why supporting them can change how you feel day to day. They also talk about tools like methylene blue and oxygen therapy, and when they can actually make a difference.

They also get into why constantly pushing harder isn't the answer, and how being able to slow your system down can actually improve your performance. You'll hear what it really means to shift into a parasympathetic state and why so many people struggle to get there. It may change the way you think about stress, recovery, and what your body actually needs.

In This Episode:

00:24 Show Intro and Guest

05:04 Sympathetic Spiral of Doom Explained

08:40 The Parasympathetic Edge

12:32 GABA Gas and Brakes System

15:22 Gut Inflammation and GABA Connection

16:49 Safer Ways to Support GABA

19:55 Alcohol, Benzos and Dependence

22:26 Why Calming Alone Can Backfire

27:13 Mitochondrial Dysfunction Root Causes

30:29 Methylene Blue as an Energy Bridge

32:40 Methylene Blue Controversies

36:20 SSRI Safety Considerations

37:47 High Dose Clinical Use

38:27 Versus CoQ10, PQQ and Creatine

41:29 Hyperbaric Oxygen Basics

43:29 Acute vs Chronic Protocols

46:01 Chamber Pressure Differences

47:17 Health Optimization Medicine Explained

49:55 Trauma and the Sympathetic Loop

55:26 Vagus Nerve Tools and Limits

01:02:54 Performance, Recovery and Closing Insights

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"Most GABA is made in the brain from glutamate using magnesium and vitamin B6. If you're deficient, your nervous system struggles to slow down."

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