Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+ Ep. 588 The GLP-1 Masterclass: The Science of Midlife Metabolic Resilience | Menopause & GLP-1s
May 2, 2026
Ashley Koff, registered dietitian focused on appetite and practical nutrition. McCall McPherson, PA-C specializing in individualized and microdosing GLP‑1 strategies. Dr. Alexandra Sowa, physician and author on GLP‑1 mechanisms and safe prescribing. Dr. Rocio Salas‑Whalen, clinician in weight management and medication combinations. Dr. Nick Norwitz, metabolic health researcher on statins and insulin biology. They discuss appetite regulation, microdosing, side‑effect management, statins' impact on GLP‑1, and combining therapies.
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Pause And Fix Digestion Before Reaching For Drugs
- Reconnect with your body before medicating appetite issues.
- McCall McPherson used digestion optimization, hemp seeds for protein/fiber, timing (3‑hour windows) and supplements to help a 42‑year‑old lose fat and stop pain meds within 90 days.
Statins Lower GLP‑1 And Raise Insulin Resistance
- Statins can reduce GLP‑1 levels and promote insulin resistance, a finding from a human randomized trial in Cell Metabolism.
- Nick Norwitz highlights this trial showed mechanisms and a cheap potential reversal, yet many physicians were unaware of it.
GLP‑1s Reduce Portions And Block Food Reward
- GLP‑1s act on both energy intake and reward pathways to reduce portions and snacking.
- Rocio Salas‑Whalen explains engineered GLP‑1s extend half‑life so they increase satiety, suppress between‑meal hunger, and blunt dopamine reward signals.
