The Ben Azadi Show #1125 Stop Aging In Its Tracks! The Incredible Longevity Molecule You’ve Never Heard Of with Dr. Andrew Salzman
Oct 13, 2025
In this fascinating discussion, Dr. Andrew Salzman, a Harvard-trained physician and pioneering NAD+ researcher, reveals how NAD+ can combat aging and boost vitality. He explains the decline of NAD+ with age and its link to energy loss and inflammation. Listeners learn about practical methods to enhance NAD+ levels through ketogenic diets, fasting, and supplements. Dr. Salzman also emphasizes the role of gratitude in longevity, making this conversation a blend of science and inspiration for those seeking to age vibrantly.
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NAD Decline Is Drain‑Driven With Age
- Think of NAD like bathtub water governed by a spigot (production) and a drain (consumption).
- Aging widens the drain more than it shuts the spigot, causing net NAD decline.
CD38 Is The NAD 'Scissors'
- CD38 is the primary enzyme that 'chews up' NAD and increases with age and inflammation.
- Elevated CD38 activity explains much of the progressive NAD depletion in older tissues.
Leaky Gut Fuels CD38 And NAD Loss
- Age-related gut barrier loss releases bacterial products that drive chronic inflammation and ramp up CD38.
- Loss of gut ATP (from low NAD) weakens intestinal seals, creating a vicious inflammation–CD38 loop.
