The Evolving Wellness Podcast with Sarah Kleiner Wellness

Peptides, HRT, Red Light & More: Why Your Genetics Determine the Outcome : Kash Khan

Jan 28, 2026

Kash (Cash) Khan, a health and genetics expert who helps translate DNA into personalized care. He talks about why genes change responses to diets like keto, how methylation and detox genes alter supplements and HRT risk, and why therapies from peptides and NAD to red light need genetic tailoring. Short, practical takes on bio-individual strategies and when common biohacks help or harm.

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INSIGHT

Keto Works Only For Some Genomes

Genetics determine whether a ketogenic diet helps or harms you.
APOA2 and TCF7L2 can make high-fat diets cause metabolic dysfunction in some people.

INSIGHT

Methylation Is A System, Not A Single Gene

Methylation is a system that regulates inflammation, nutrient conversion, toxin clearance, and gene expression.
You must view MTHFR within the whole methylation system, not as a single cause.

ADVICE

Check Homocysteine Before Drastic Measures

Measure homocysteine and correct modest elevations with targeted B‑vitamins.
Fill biochemical gaps first before assuming you need medications.

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Save your seat: https://www.hackmydna.com/sarah

In this episode of the Evolving Wellness Podcast, host Sarah and her guest Cash discuss the complexities of personalized health strategies, focusing on genetic variability and its impact on diet, hormones, and therapies like peptides and red light therapy. They explore the differences in how individuals react to ketogenic diets, the role of specific genes like APO A2 and TCF 7L2 in metabolic health, and the nuances of using biohacking tools such as NAD and glutathione. They emphasize the importance of understanding genetic profiles for effective and safe health interventions. Sarah announces an upcoming free webinar for deeper dives into these topics and audience Q&A. The episode underlines the necessity of a bio-individual approach for optimal wellness.

About Hack My DNA’s Mission:

Hack My DNA is focused on helping people understand and optimize their health by using their unique genetic blueprint. Founded by Sarah, the platform bridges the gap between raw DNA data and real-life action—translating genetic insights into practical strategies for nutrition, lifestyle, and long-term wellness. Hack My DNA’s mission is to empower individuals to make informed, personalized health decisions by uncovering how their genes influence everything from metabolism and detoxification to inflammation and aging, so they can live healthier, more intentional lives

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