The Curbsiders Internal Medicine Podcast REBOOT #151 Anaphylaxis
Mar 30, 2022
Recognize common presentations of anaphylaxis, diagnosing criteria, and treatment basics. Importance of epinephrine and utility of adjunctive therapies. Tips on counseling patients about auto-injectable epinephrine and a reminder not to panic. Overview of the podcast format and introduction to the guest speaker. Book recommendations, advice for fellows, and career goals. Discussion on biphasic reactions, predicting severity, and monitoring recommendations. Importance of educating patients on epinephrine usage.
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First-Time Reactions
- A first-time reaction to a substance isn't IgE-mediated because sensitization requires prior exposure.
- Anaphylactoid reactions often respond to pre-medication, unlike IgE-mediated reactions.
Vancomycin vs. Contrast Reactions
- Red man syndrome, a non-IgE-mediated reaction to vancomycin, is usually mild and managed by slowing the infusion or pre-treating with antihistamines.
- This contrasts with potentially severe reactions to radiocontrast media.
Anaphylaxis Presentations
- Anaphylaxis presents in various ways; one involves skin/mucosa and respiratory or blood pressure issues.
- Another involves two or more organ systems (skin, respiratory, GI, cardiovascular) after allergen exposure.