
The Human Upgrade: Biohacking for Longevity & Performance Scientists Disrupt the Aging Game - James Peyer : 569
Feb 21, 2019
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Launch Aging Drugs Via Accepted Indications
- Develop longevity drugs by targeting an accepted clinical indication first, then expand approved uses to aging-related benefits.
- Use FDA pathways to approve for disease indications and later flip labels to broader preventive uses across multiple conditions.
Grandfather's Cancer Sparked A Lifelong Mission
- James Peyer became passionate about aging after his grandfather's cancer at 15, which gave purpose to his research and investing career.
- He compares aging pressure to a countdown vest that motivates focusing on removing that timer.
Biomarkers Are The Bridge To Regulatory Approval
- Aging biomarkers like epigenetic clocks can compress trial time and serve as surrogate endpoints for FDA approval.
- Cholesterol's history shows biomarkers let drugs be approved faster without lifespan trials.
