LEVELS – A Whole New Level

#285 - Immune health explained: Inflammation, white blood cells, and resilience | Dr. Sharon Bergquist & Mike Haney

Nov 6, 2025
Dr. Sharon Bergquist, a physician-scientist and director at Emory’s Healthy Aging Center, dives into the complex interplay between immune health and metabolic function. She explains the dual nature of inflammation, discussing how it can both protect and harm. The conversation highlights the significance of white blood cells in assessing immunity and stress levels. Dr. Bergquist shares practical tips to cultivate immune resilience through diet, exercise, and lifestyle tweaks, emphasizing the importance of regulating rather than boosting the immune system.
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INSIGHT

New Markers Are Emerging But Early

  • Many cytokines (TNF-α, IL-6) are transient and mainly used in research rather than routine practice.
  • Composite acute-phase markers and methylation-based immune-age clocks are emerging but still early.
INSIGHT

Stress, Cortisol Resistance, And Immunometabolism

  • Chronic psychological stress can cause glucocorticoid resistance, reducing cortisol's anti-inflammatory effect.
  • Immunity is tightly linked to brain, gut, and metabolism; immunometabolism is a crucial driver of chronic inflammation.
INSIGHT

Visceral Fat Drives Inflammation

  • Visceral (belly) fat is metabolically active and secretes pro-inflammatory cytokines.
  • Fat distribution and genetic capacity to store subcutaneous fat explain why some obese people remain metabolically healthier.
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