Evolution of Medicine Podcast Your Best Shot: Holistic Approach to GLP-1
7 snips
Feb 23, 2026 
Ashley Koff, RD, a registered dietitian and functional nutrition expert focused on metabolic and weight health, explains a weight-health, hormone-centered approach to GLP-1 therapies. She reframes GLP-1s as biosimilar hormone tools and stresses repairing underlying metabolism. Short takes cover a five-part assessment, team-based dietitian–physician–coach care, physiology of GLP-1s, and practical alternatives and safeguards.
AI Snips
Chapters
Books
Transcript
Episode notes
GLP-1s Are Biosimilar Hormone Replacement Tools
- GLP-1 agonists are best framed as biosimilar hormone replacement tools that reveal existing suboptimal hormone systems.
- Ashley Koff traced her work from bariatric observations to the incretin effect and concluded meds show the system around hormones needs repair.
Be Agnostic About The Agonist Focus On System Quality
- Be agnostic about which agonist you use and focus on dose quality, system support, and appropriate patient selection.
- Ashley advises clinicians to decide based on how much repair a patient can achieve without medication and to avoid rigid camps.
Assess And Repair Hormone Ecosystem With A Five Part Plan
- Do assess and repair weight health hormone function before or alongside starting an agonist using a structured clinical assessment.
- Ashley recommends a five-part clinical assessment (labs, CPM, gut, vagus, blood flow) and using targeted interventions like gut repair or New Zealand hops when appropriate.
