The Curbsiders Internal Medicine Podcast REBOOT #421 Antiphospholipid Syndrome with Dr. Arielle Langer
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Jan 6, 2025 Dr. Arielle Langer, an assistant professor at Harvard Medical School and director of various specialized programs, dives into antiphospholipid syndrome's clinical features, testing, and management strategies. She breaks down the diagnostic challenges, emphasizing the need for precise differentiation between true cases and false positives. Langer also discusses the complexities of managing this condition, particularly in pregnancy, and highlights the importance of patient education and collaboration with specialists for optimal care.
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Quitting Soccer
- Dr. Langer quit her high school soccer team captaincy to pursue cross-country running.
- This taught her the importance of recognizing when to move on, even if difficult.
Understanding APS
- Antiphospholipid syndrome (APS) is an autoimmune disorder affecting clotting proteins.
- Unlike other autoimmune disorders that destroy targets, APS activates them, accelerating clotting.
Clinical Indicators for APS Testing
- Suspect APS in patients with aggressive or unusual clotting (e.g., arterial clots, splanchnic thrombosis).
- Also, consider host factors like autoimmune history (especially lupus).