The Curbsiders Internal Medicine Podcast #441 More Clinical Pearls (New antibiotics, syphilis, heart disease, cirrhosis, lots more!) from ACP #IM2024
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May 27, 2024 
Experts Nora Taranto, Beth Garbitelli, and Chris Chiu share insights on new antibiotics, syphilis resurgence, cirrhosis management, HFpEF, SGLT2i for gout, and CAR T-cells. Topics range from tropical diseases to autoimmune conditions, offering a diverse medical perspective.
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Tropical Diseases Returning To The US
- Malaria, dengue, and other tropical infections are re-emerging in parts of the US due to warming and ecological changes.
- Clinicians must consider locally acquired vector-borne diseases even without travel history.
Syphilis Resurgence And Public Health Gaps
- Syphilis rates have climbed to levels not seen since the antibiotic era and are still penicillin-sensitive.
- Public-health gaps and limited follow-up contribute to rising congenital syphilis and treatment failures.
Managing C. difficile And Recurrence
- Use fidaxomicin or oral vancomycin as first-line therapy for C. difficile and consider adjuncts for recurrence risk.
- Reserve fecal microbiota products (RBX2660, SER-109) for recurrent disease while weighing cost and availability.