Dhru Purohit Show

A Doctor’s Argument For Why Most Diet’s Fail: The Hidden Hormone Problem Driving Weight Gain and What To Do About It with Dr. Jason Fung

Mar 11, 2026
Dr. Jason Fung, nephrologist and bestselling author known for work on fasting and obesity. He argues hunger and hormones—not willpower—drive weight gain. Short, punchy sections explore three types of hunger, a body “fat thermostat,” how ultra-processed foods hijack hormones, GLP-1 drugs’ role, and three rules to reset hunger naturally.
Ask episode
AI Snips
Chapters
Books
Transcript
Episode notes
ADVICE

Target Hormones Not Just Calories

  • To change weight long-term you must alter the hormonal thermostat, not only calorie intake.
  • Fix diet patterns that chronically raise insulin (ultra-processed foods) or consider interventions that lower insulin signaling.
INSIGHT

Food Matrix Dictates Hormonal Spike

  • Food processing changes the food matrix and digestion speed, driving larger insulin spikes.
  • Pureed or instant forms (applesauce, instant oats) are pre-digested, cause faster glucose absorption and higher insulin than whole foods.
ADVICE

Avoid Ultra-Processed Foods

  • Avoid ultra-processed foods because they attack multiple hunger pathways at once.
  • They are engineered for rapid absorption, maximal dopamine reward and reduced satiety signaling, making them highly addictive.
Get the Snipd Podcast app to discover more snips from this episode
Get the app