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Importance of Lipoprotein(a) Testing
- Lipoprotein(a) is highly heritable and a strong causal risk factor for ASCVD and aortic stenosis.
- Measuring it helps identify high-risk patients even when LDL is low, guiding potential therapies.
Manage Elevated Lipoprotein(a)
- Measure lipoprotein(a) at least once, especially in those with personal or family ASCVD history.
- Use PCSK9 inhibitors to lower lipoprotein(a) by 20-25% when additional LDL lowering is needed.
Statins and Lipoprotein(a) Relationship
- Statins do not lower lipoprotein(a) and may even increase it.
- Despite this, statins remain crucial to reduce overall cardiovascular events.