Low testosterone is sabotaging your health, motivation, and longevity. Diet alone will not fix it.
In this episode of The Human Upgrade, Dave Asprey sits down with Shalin Shah, CEO of Marius Pharmaceuticals, to expose the truth about testosterone decline in both men and women. They break down why testosterone is crashing worldwide, why natural fixes almost always fail, and how the latest science finally makes testosterone therapy safer, simpler, and more effective than ever before.
You will discover why testosterone is essential for dopamine, brain function, sleep, muscle, libido, and mitochondrial health. Fixing your levels can reverse fatigue, brain fog, poor motivation, and slow aging itself.
Shalin reveals how new oral testosterone technology (Kyzatrex®) overcomes the dangers of old therapies and restores natural hormone rhythms without needles, creams, or dangerous side effects.
What You Will Learn in This Episode:
• Why testosterone matters for men and women at every age
• The real causes of the global testosterone crash
• Why diet, sleep, and exercise cannot fully fix low testosterone
• How testosterone drives dopamine, motivation, and longevity
• The breakthrough that makes oral testosterone safe and effective
• How Kyzatrex® lowers SHBG and boosts free testosterone naturally
• Why maintaining youthful testosterone levels protects brain, muscle, libido, and lifespan
• How to safely use testosterone therapy without suppressing fertility or causing side effects
** Visit livethrive.co/asprey to get a discount on your first month's supply! **
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Purchase Kyzatrex® – https://livethrive.co/?utm_campaign=11813552-Asprey
• Shalin’s Instagram - https://www.instagram.com/themetabolicceo/
• 2025 Biohacking Conference: https://biohackingconference.com/2025
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
00:00 Trailer
00:52 Introduction
01:29 Global Decline in Testosterone Levels
02:27 Symptoms of Low Testosterone
03:48 Personal Journey with Testosterone Therapy
05:06 The Role of Testosterone in Overall Health
06:18 Testosterone Levels in Men and Women
08:48 Challenges and Innovations in Testosterone Delivery
16:25 The Importance of Circadian Rhythm in Testosterone Therapy
19:19 The Future of Testosterone Therapy
32:00 Investment and Development in Testosterone Therapy
34:57 Introduction to FDA and Hormone Replacement
35:31 FDA’s Impact on Women’s Health
36:10 Testosterone and Cardiovascular Risk
39:05 Testosterone and Depression
40:30 Testosterone Testing and Misconceptions
44:58 The Testosterone Project and Female Hormone Therapy
47:51 Testosterone’s Role in Longevity and Health
55:37 Cost and Accessibility of Testosterone Therapy
01:04:03 Conclusion and Final Thoughts
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The Human Upgrade: Biohacking for Longevity & Performance 
