The Curbsiders Internal Medicine Podcast #319 Hotcakes: Afib, Chlorthalidone in CKD, Outpatient COVID Treatment Update
Jan 31, 2022
AI Snips
Chapters
Transcript
Episode notes
Patient-Led N-of-1 Trials In Afib
- N-of-1 trials let patients test their own triggers for paroxysmal atrial fibrillation.
- The I-STOP Afib trial found no average improvement in AF-related quality of life despite some trigger-related effects.
When To Use N-of-1 Designs
- Use n-of-1 designs for stable conditions with clear symptoms or biomarkers and quick on/off treatment effects.
- Avoid them for catastrophic or slowly progressive outcomes like MI or death.
I-STOP Afib Trial Structure
- I-STOP Afib let patients choose triggers and alternate exposure versus avoidance weeks over 6–10 weeks.
- Patients could repeat with different triggers, enabling individualized treatment effect estimates aggregated by meta-analysis.