The Jesse Chappus Show 668: This Stops Insulin Resistance in Its Tracks | Dr. Roshani Sanghani
12 snips
Sep 2, 2025 Dr. Roshani Sanghani, a board-certified endocrinologist and metabolic health practitioner, shares her expertise on insulin resistance and hormone optimization. Listeners learn about the importance of proactive health screenings, especially for those of Indian descent. She emphasizes lifestyle changes, like time-restricted eating and low-carb diets, to combat insulin resistance. The discussion also covers the impact of chronic stress, the role of strength training in diabetes management, and the nuances of vegetarian dietary practices for metabolic health.
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Liver Is A Glucose Provider, Not A Fat Depot
- The liver provides glucose via gluconeogenesis and is vulnerable to fructose-driven fat accumulation.
- Fatty liver arises from high insulin plus high fructose and can progress even with small fat deposits.
Pancreas Can Burn Out — Test C-Peptide
- Pancreatic fat can infiltrate and damage insulin-producing cells, leading to declining insulin production.
- C-peptide testing distinguishes pancreas burnout from reversible dysfunction and guides treatment.
Doctor's Own Prediabetes Sparked Her Shift
- Roshani shares that she became prediabetic in 2013 with an A1c of 6.3 while eating high-carb.
- Her personal stress, mindset change and later low-carb adoption drove her professional shift to metabolic care.
