Siim Land Podcast #440 GENETICS Based Supplements You Should AVOID - Dr Tyler Panzner
Feb 15, 2025
Dr. Tyler Panzner, an expert in genetics and personalized medicine, shares insights on how our genes influence supplement effectiveness. He reveals the genetic factors affecting caffeine and creatine metabolism. The discussion also explores the complexities of supplements like glycine and the impact of diet on food sensitivities. Tyler highlights the importance of individualized nutrition strategies, particularly regarding vitamin D and omega-3s, while addressing common misconceptions in the realm of health supplements.
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Creatine Considerations
- Creatine, while generally safe, can cause anxiety or hair loss in individuals sensitive to adrenaline or with high DHT levels.
- Consider combining creatine with DHT-lowering supplements like saw palmetto or reishi mushroom.
Agmatine for Pumps
- Tyler Panzner discovered he had mutations in the NOS3 gene, which synthesizes nitric oxide.
- Switching from arginine to agmatine resulted in significantly improved pumps during workouts.
Glycine and Glutamate
- Glycine, though beneficial, can cause headaches, insomnia, or nausea due to its role in glutamate signaling.
- Consider magnesium supplementation, which blocks the NMDA receptor, to mitigate negative effects.
