#610: The Life-Extension Episode — Dr. Matt Kaeberlein on The Dog Aging Project, Rapamycin, Metformin, Spermidine, NAD+ Precursors, Urolithin A, Acarbose, and Much More

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Jul 27, 2022

Dr. Matt Kaeberlein, a leading researcher on aging from the University of Washington, dives into groundbreaking insights about longevity. He discusses the Dog Aging Project, revealing how canine studies can inform human health. The conversation highlights promising compounds like rapamycin and metformin and their role in extending healthspan. Kaeberlein also shares his personal experiences with aging research, dietary strategies for dogs, and the need for innovative funding in the pursuit of longevity. Tune in for a fascinating look at the future of aging!

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INSIGHT

Rapamycin's Uses and Effects

Rapamycin, typically used to prevent organ transplant rejection, reduces age-related sterile inflammation (inflammation not caused by infection).
It can seemingly reboot the aged immune system, improving its response to vaccines in mice.

INSIGHT

Aging Immune System Dysfunction

The aging immune system both underreacts to pathogens and overreacts through sterile inflammation, possibly due to accumulated senescent cells.
Senescent cells emit inflammatory signals, contributing to chronic inflammation and hindering immune response.

INSIGHT

Senolytics vs. Rapamycin

Senolytics aim to kill senescent cells, while rapamycin suppresses their inflammatory signals (SASP).
Rapamycin may indirectly clear senescent cells by rebooting the immune system, allowing it to clear them.

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The Life-Extension Episode — Dr. Matt Kaeberlein on The Dog Aging Project, Rapamycin, Metformin, Spermidine, NAD+ Precursors, Urolithin A, Acarbose, and Much More | Brought to you by Levels real-time feedback on how diet impacts your health, Athletic Greens all-in-one nutritional supplement, and LMNT electrolyte supplement. More on all three below.

Dr. Matt Kaeberlein (@mkaeberlein) is a professor of Laboratory Medicine and Pathology at the University of Washington School of Medicine, with adjunct appointments in Genome Sciences and Oral Health Sciences. Dr. Kaeberlein’s research interests are focused on understanding biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life for people and companion animals.

Dr. Kaeberlein is the founding director of the University of Washington Healthy Aging and Longevity Research Institute, the director of the NIH Nathan Shock Center of Excellence in the Basic Biology of Aging at the University of Washington, director of the Biological Mechanisms of Healthy Aging Training Program, and founder and co-director of the Dog Aging Project.

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[06:44] What is aging biology?

[08:43] How Matt pivoted from mathematics to biology.

[11:46] What is the Dog Aging Project?

[13:42] Understanding healthspan through Matt’s frozen shoulder ordeal.

[20:23] Rapamycin vs. sterile inflammation.

[23:07] Current thoughts about how the immune system changes as we age.

[29:11] Anti-aging uses for rapamycin (and potential risks/side effects).

[42:20] Rapamycin and the Dog Aging Project.

[45:30] Rapamycin vs. neurodegeneration.

[48:21] What studies tell us about rapamycin’s potential to increase lifespan.

[51:30] Rapamycin alternatives considered for the Dog Aging Project.