The Jesse Chappus Show 670: The Fastest Way to Regain Your Energy (Without Caffeine) | Dr. Sarah Myhill
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Sep 16, 2025 
Dr. Sarah Myhill is a seasoned medical practitioner focused on Chronic Fatigue Syndrome and ME. In this engaging conversation, she discusses how energy delivery systems influence overall health and the critical role of diet in energy production. She advocates for paleo ketogenic and carnivore diets, emphasizing their benefits in combating sugar addiction. The duo dives into human evolution and dietary changes impacting health. Myhill also unravels mitochondrial function, offering insights into effective strategies for detoxification and managing chronic fatigue.
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A Five-Part Mitochondrial Package
- For pathological fatigue, supplement key mitochondrial cofactors: magnesium, CoQ10, niacinamide, acetyl-L-carnitine, and D-ribose.
- Use suggested doses: Mg 200 mg (+Vit D), CoQ10 100 mg, niacinamide 1500 mg, ALC 1 g, D-ribose 5–10 g.
Lactic Acid Is A Mitochondrial Brake
- Lactic acid from anaerobic metabolism inhibits mitochondria and causes prolonged crashes in pathologically fatigued patients.
- Aerobic ATP (36 per acetate) is far more efficient than anaerobic ATP (2 per acetate).
Pace To Avoid Post-Exertional Crashes
- Pace activity so you never pay for exertion the next day; increase work only when you can do the same activity daily without delayed fatigue.
- Use small, consistent daily limits and build up slowly as diet and supplements improve mitochondrial capacity.
