Untangle Is it Possible to Age-Proof your Brain and Slow Cognitive Decline? With Dr. Majid Fotuhi
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Mar 3, 2026 
Dr. Majid Fotuhi, neurologist, neuroscientist and Johns Hopkins adjunct professor, explains neuroplasticity and how the brain can rewire and grow at any age. He explores the “soup of abnormalities” behind Alzheimer’s, the five pillars of brain health, diet and supplements, and practical strategies to slow cognitive decline. Short, actionable science with a hopeful take on aging.
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Brain Can Rewire Throughout Life
- Neuroplasticity means the brain can rewire and grow at any age, not only after injury.
- Dr. Majid Fotuhi lists mechanisms: new neurons, blood vessels, synapses, and connections that lifestyle can activate.
Alzheimer Symptoms Come From A Mix Not Just Plaques
- Alzheimer's symptoms usually result from a 'soup' of factors: plaques/tangles plus lifestyle-driven issues like inflammation and reduced blood flow.
- The NUN study showed people with plaques but healthy brains had no symptoms, implying resilience matters.
Whole Body Drives Brain Health
- Every organ influences brain health via blood flow, hormones, and inflammation, so body systems are tightly interconnected.
- Examples: heart failure reduces cerebral perfusion, gut dysbiosis causes 'leaky brain', muscles release myokines like BDNF.
