EB. 128: Are Oxalates the Problem, or Is It Your Gut?

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Feb 13, 2025

Is it time to rethink the fear around oxalates? The podcast dives into whether their harmful effects are overblown and how your gut health plays a crucial role in managing oxalate issues. Discover which nutrients can help reduce oxalate absorption and the surprising link between fat digestion and oxalate metabolism. They also discuss how conditions like candida overgrowth might be influencing your body's oxalate challenges. Plus, the conversation touches on the impact of calcium and magnesium in this complex relationship.

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INSIGHT

Gut Dysbiosis

High oxalate levels can disrupt gut microbiota, including beneficial oxalate-metabolizing bacteria.
This dysbiosis can create a vicious cycle, worsening oxalate-related issues like kidney stones.

INSIGHT

Metabolic Effects

Oxalates cause mitochondrial dysfunction, reducing energy production and increasing oxidative stress.
Glutathione protects against oxalate damage, while mitochondrial dysfunction increases susceptibility to oxalate deposition.

ADVICE

Antioxidant Protection

Consume a low-PUFA diet to reduce lipid peroxidation and increase vitamin E levels.
Ensure sufficient antioxidant status through vitamin E and C to mitigate oxalate-induced oxidative damage.

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In this episode we discuss:

Whether the harmful effects of oxalates are legitimate or overblown
How your gut health impacts your susceptibility to oxalate issues
Which nutrients help decrease oxalate absorption
How fat digestion relates to oxalate absorption
Whether a candida overgrowth may be at the root of your oxalate issues

Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-128-are-oxalates-the-problem-or-is-it-your-gut/

Timestamps:

0:00 – intro

1:08 – common misconceptions about oxalates and whether oxalate concerns are justified

5:21 – symptoms often attributed to oxalates and whether they are truly responsible for most health problems

12:48 – what are oxalates?

16:18 – oxalates cause kidney damage and reduce mineral bioavailability

21:34 – oxalates and cardiovascular disease

24:43 – oxalates as a driver of gut dysbiosis and decreased bile acid production

29:16 – metabolic damage caused by oxalates

37:06 – how a low-PUFA diet and vitamin E can protect against oxalate damage

43:19 – high oxalate foods and factors that impact oxalate absorption

53:29 – soluble vs. insoluble oxalates

57:04 – how calcium affects oxalate absorption and the impact of parathyroid hormone and 1,25-Dihydroxyvitamin D

1:07:41 – the effects of magnesium on oxalate absorption

1:12:44 – how deficiencies in vitamin B1 (thiamine) and vitamin B6 can increase oxalate levels

1:14:44 – how gut health relates to oxalate issues (fat digestion, intestinal permeability, and oxalate degrading bacteria)

1:22:23 – “oxalate dumping” on low-carb diets and carnivore diets may be due to poor gut health

1:26:15 – whether candida infections or other fungal infections cause excess oxalate production