Siim Land Podcast #356 Glycine for Longevity Masterclass
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Apr 10, 2023 Discover the benefits of glycine for longevity, including improved blood sugar levels, enhanced physical function in older adults, and anti-aging properties. Explore the impact of glycine on collagen turnover, muscle health, and sleep quality, as well as its importance in balancing methionine intake for optimal health and longevity.
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Glycine Mimics Methionine Restriction
- Glycine extends lifespan in worms, mice and rats by inducing autophagy and mimicking methionine restriction.
- It buffers methionine toxicity and may reproduce methionine-restriction benefits without drastically cutting animal protein.
Consistent Lifespan Gains In Animals
- Animal studies show large lifespan gains: up to ~28% in male rats and smaller but consistent increases in flies and mice.
- Lifespan benefits appear across species, supporting a conserved longevity effect.
Practical Human Dosing From Trials
- Clinical trials used 3–15 grams daily and showed improvements in A1c, blood pressure, stroke outcomes, bladder function, and fatigue.
- Consider starting with 3–5 g with meals or 5 g before bed, adjusting toward 5–10 g/day for broader benefits.